Protein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO)

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dc.citation.issue9
dc.citation.volume11
dc.contributor.authorMitchell SM
dc.contributor.authorMilan AM
dc.contributor.authorMitchell CJ
dc.contributor.authorGillies NA
dc.contributor.authorD'Souza RF
dc.contributor.authorZeng N
dc.contributor.authorRamzan F
dc.contributor.authorSharma P
dc.contributor.authorKnowles SO
dc.contributor.authorRoy NC
dc.contributor.authorSjödin A
dc.contributor.authorWagner K-H
dc.contributor.authorZeisel SH
dc.contributor.authorCameron-Smith D
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-10-18T01:39:14Z
dc.date.available2024-10-18T01:39:14Z
dc.date.issued2019-09-12
dc.description.abstractHigher dietary protein intake is increasingly recommended for the elderly; however, high protein diets have also been linked to increased cardiovascular disease (CVD) risk. Trimethylamine-N-oxide (TMAO) is a bacterial metabolite derived from choline and carnitine abundant from animal protein-rich foods. TMAO may be a novel biomarker for heightened CVD risk. The purpose of this study was to assess the impact of a high protein diet on TMAO. Healthy men (74.2 ± 3.6 years, n = 29) were randomised to consume the recommended dietary allowance of protein (RDA: 0.8 g protein/kg bodyweight/day) or twice the RDA (2RDA) as part of a supplied diet for 10 weeks. Fasting blood samples were collected pre- and post-intervention for measurement of TMAO, blood lipids, glucose tolerance, insulin sensitivity, and inflammatory biomarkers. An oral glucose tolerance test was also performed. In comparison with RDA, the 2RDA diet increased circulatory TMAO (p = 0.002) but unexpectedly decreased renal excretion of TMAO (p = 0.003). LDL cholesterol was increased in 2RDA compared to RDA (p = 0.049), but no differences in other biomarkers of CVD risk and insulin sensitivity were evident between groups. In conclusion, circulatory TMAO is responsive to changes in dietary protein intake in older healthy males.
dc.description.confidentialfalse
dc.edition.editionSeptember 2019
dc.format.paginationE2207-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/31547446
dc.identifier.citationMitchell SM, Milan AM, Mitchell CJ, Gillies NA, D'Souza RF, Zeng N, Ramzan F, Sharma P, Knowles SO, Roy NC, Sjödin A, Wagner K-H, Zeisel SH, Cameron-Smith D. (2019). Protein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO).. Nutrients. 11. 9. (pp. E2207-).
dc.identifier.doi10.3390/nu11092207
dc.identifier.eissn2072-6643
dc.identifier.elements-typejournal-article
dc.identifier.issn2072-6643
dc.identifier.numberARTN 2207
dc.identifier.piinu11092207
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71761
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2072-6643/11/9/2207
dc.relation.isPartOfNutrients
dc.rights(c) 2019 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCVD
dc.subjectCVD biomarkers
dc.subjectTMAO
dc.subjectelderly
dc.subjecthigh protein diet
dc.subjectAged
dc.subjectBiomarkers
dc.subjectCardiovascular Diseases
dc.subjectCholesterol, LDL
dc.subjectDiet, High-Protein
dc.subjectDietary Proteins
dc.subjectFasting
dc.subjectGastrointestinal Microbiome
dc.subjectHumans
dc.subjectInsulin Resistance
dc.subjectLipids
dc.subjectMale
dc.subjectMethylamines
dc.subjectRecommended Dietary Allowances
dc.subjectRisk Factors
dc.titleProtein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO)
dc.typeJournal article
pubs.elements-id434468
pubs.organisational-groupOther
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