Genome-Wide Association Studies of Live Weight at First Breeding at Eight Months of Age and Pregnancy Status of Ewe Lambs

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dc.citation.issue4
dc.citation.volume14
dc.contributor.authorHaslin E
dc.contributor.authorPettigrew EJ
dc.contributor.authorHickson RE
dc.contributor.authorKenyon PR
dc.contributor.authorGedye KR
dc.contributor.authorLopez-Villalobos N
dc.contributor.authorJayawardana JMDR
dc.contributor.authorMorris ST
dc.contributor.authorBlair HT
dc.contributor.editorAhmad SM
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-06-19T01:15:30Z
dc.date.available2024-06-19T01:15:30Z
dc.date.issued2023-03-27
dc.description.abstractThis study estimated genetic parameters and identified candidate genes associated with live weight, and the occurrence of pregnancy in 1327 Romney ewe lambs using genome-wide association studies. Phenotypic traits considered were the occurrence of pregnancy in ewe lambs and live weight at eight months of age. Genetic parameters were estimated, and genomic variation was assessed using 13,500 single-nucleotide polymorphic markers (SNPs). Ewe lamb live weight had medium genomic heritability and was positively genetically correlated with occurrence of pregnancy. This suggests that selection for heavier ewe lambs is possible and would likely improve the occurrence of pregnancy in ewe lambs. No SNPs were associated with the occurrence of pregnancy; however, three candidate genes were associated with ewe lamb live weight. Tenascin C (TNC), TNF superfamily member 8 (TNFSF8) and Collagen type XXVIII alpha 1 chain (COL28A1) are involved in extracellular matrix organization and regulation of cell fate in the immune system. TNC may be involved in ewe lamb growth, and therefore, could be of interest for selection of ewe lamb replacements. The association between ewe lamb live weight and TNFSF8 and COL28A1 is unclear. Further research is needed using a larger population to determine whether the genes identified can be used for genomic selection of replacement ewe lambs.
dc.description.confidentialfalse
dc.edition.editionApril 2023
dc.format.pagination805-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37107563
dc.identifier.citationHaslin E, Pettigrew EJ, Hickson RE, Kenyon PR, Gedye KR, Lopez-Villalobos N, Jayawardana JMDR, Morris ST, Blair HT. (2023). Genome-Wide Association Studies of Live Weight at First Breeding at Eight Months of Age and Pregnancy Status of Ewe Lambs.. Genes (Basel). 14. 4. (pp. 805-).
dc.identifier.doi10.3390/genes14040805
dc.identifier.eissn2073-4425
dc.identifier.elements-typejournal-article
dc.identifier.issn2073-4425
dc.identifier.number805
dc.identifier.piigenes14040805
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/69905
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2073-4425/14/4/805
dc.relation.isPartOfGenes (Basel)
dc.subjectcandidate genes
dc.subjectfertility
dc.subjectgenomic heritability
dc.subjectgrowth
dc.subjectFemale
dc.subjectPregnancy
dc.subjectSheep
dc.subjectAnimals
dc.subjectGenome-Wide Association Study
dc.subjectSheep, Domestic
dc.subjectWeaning
dc.subjectPhenotype
dc.titleGenome-Wide Association Studies of Live Weight at First Breeding at Eight Months of Age and Pregnancy Status of Ewe Lambs
dc.typeJournal article
pubs.elements-id461194
pubs.organisational-groupOther
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