Gut-Brain Axis in the Early Postnatal Years of Life: A Developmental Perspective

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dc.citation.volume14
dc.contributor.authorJena A
dc.contributor.authorMontoya CA
dc.contributor.authorMullaney JA
dc.contributor.authorDilger RN
dc.contributor.authorYoung W
dc.contributor.authorMcNabb WC
dc.contributor.authorRoy NC
dc.contributor.editorCammarota M
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-10-22T02:20:35Z
dc.date.available2024-10-22T02:20:35Z
dc.date.issued2020-08-05
dc.description.abstractEmerging evidence suggests that alterations in the development of the gastrointestinal (GI) tract during the early postnatal period can influence brain development and vice-versa. It is increasingly recognized that communication between the GI tract and brain is mainly driven by neural, endocrine, immune, and metabolic mediators, collectively called the gut-brain axis (GBA). Changes in the GBA mediators occur in response to the developmental changes in the body during this period. This review provides an overview of major developmental events in the GI tract and brain in the early postnatal period and their parallel developmental trajectories under physiological conditions. Current knowledge of GBA mediators in context to brain function and behavioral outcomes and their synthesis and metabolism (site, timing, etc.) is discussed. This review also presents hypotheses on the role of the GBA mediators in response to the parallel development of the GI tract and brain in infants.
dc.description.confidentialfalse
dc.format.pagination44-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/32848651
dc.identifier.citationJena A, Montoya CA, Mullaney JA, Dilger RN, Young W, McNabb WC, Roy NC. (2020). Gut-Brain Axis in the Early Postnatal Years of Life: A Developmental Perspective.. Front Integr Neurosci. 14. (pp. 44-).
dc.identifier.doi10.3389/fnint.2020.00044
dc.identifier.eissn1662-5145
dc.identifier.elements-typejournal-article
dc.identifier.issn1662-5145
dc.identifier.numberARTN 44
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71799
dc.languageeng
dc.publisherFrontiers Media S.A.
dc.publisher.urihttps://www.frontiersin.org/journals/integrative-neuroscience/articles/10.3389/fnint.2020.00044/full
dc.relation.isPartOfFront Integr Neurosci
dc.rights(c) 2020 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectbrain
dc.subjectcognition
dc.subjectgastrointestinal tract
dc.subjectgut-brain axis
dc.subjectmetabolites
dc.subjectmicrobiota
dc.subjectpostnatal development
dc.titleGut-Brain Axis in the Early Postnatal Years of Life: A Developmental Perspective
dc.typeJournal article
pubs.elements-id434427
pubs.organisational-groupOther
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