An Evaluation of Different Digestion Methods for the Quantitation of Inorganic Elements in Human Hair Using ICP-MS.

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dc.citation.issue1
dc.citation.volume2022
dc.contributor.authorLiu Y
dc.contributor.authorYang Y
dc.contributor.authorXia Y-Y
dc.contributor.authorde Seymour JV
dc.contributor.authorZhao D-Z
dc.contributor.authorLi Y-M
dc.contributor.authorZhang H
dc.contributor.authorHan T-L
dc.contributor.editorKowalski R
dc.coverage.spatialEgypt
dc.date.accessioned2024-10-15T22:19:04Z
dc.date.available2024-10-15T22:19:04Z
dc.date.issued2022-12-01
dc.description.abstractThe inorganic elements have unique properties in biochemical processes in humans. An increasing number of pathologies have been associated with essential element ions, such as lead, mercury, and cadmium. Hair has become an attractive clinical specimen for studying the longitudinal exposure to elements from the external environment. Inductively coupled plasma-mass spectrometry (ICP-MS) coupled with nitric acid (HNO3) digestion is the most common approach for determining inorganic elements from human hair. This study aims to optimize the digestion method for the absolute quantitation of 52 elements using ICP-MS, for a large cohort study in human hair. Five different HNO3 (65%) digestion methods were investigated and evaluated for their internal standard solution stability, reproducibility, element coverage, and standard solution recovery efficiency, namely, room temperature for 24 h (RT), 90°C for 4 h (T90), ultrasonic-assisted digestion (UltraS), programmed digestion of microwave digestion (MicroD), and ordinary microwave oven digestion (O-MicroD). Our results demonstrated that O-MicroD, MicroD, and RT were the best performing digestion methods for coefficient of variation (CV) scores, coverage, and recovery efficiency, respectively. In particular, the O-MicroD method detected multiple elements in a small quantity of hair (3 mg), with minimum nitric acid usage (200 μl) and a short digestion time (30 min). The O-MicroD method had excellent reproducibility, as demonstrated by a continuous thousand injections of hair samples with three internal standards (CV: 103Rh = 3.59%, 115In = 3.61%, and 209Bi = 6.31%). Future studies of the elemental content of hair should carefully select their digestion method to meet the primary purpose of their study.
dc.description.confidentialfalse
dc.edition.editionJan 2022
dc.format.pagination5742468-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/36507105
dc.identifier.citationLiu Y, Yang Y, Xia Y-Y, de Seymour JV, Zhao D-Z, Li Y-M, Zhang H, Han T-L. (2022). An Evaluation of Different Digestion Methods for the Quantitation of Inorganic Elements in Human Hair Using ICP-MS.. J Anal Methods Chem. 2022. 1. (pp. 5742468-).
dc.identifier.doi10.1155/2022/5742468
dc.identifier.eissn2090-8873
dc.identifier.elements-typejournal-article
dc.identifier.issn2090-8865
dc.identifier.number5742468
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71737
dc.languageeng
dc.publisherJohn Wiley and Sons
dc.publisher.urihttps://onlinelibrary.wiley.com/doi/10.1155/2022/5742468
dc.relation.isPartOfJ Anal Methods Chem
dc.rights(c) 2022 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleAn Evaluation of Different Digestion Methods for the Quantitation of Inorganic Elements in Human Hair Using ICP-MS.
dc.typeJournal article
pubs.elements-id491142
pubs.organisational-groupCollege of Health
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