Lifestyle and incident dementia: A COSMIC individual participant data meta-analysis

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dc.citation.issue6
dc.citation.volume20
dc.contributor.authorVan Asbroeck S
dc.contributor.authorKöhler S
dc.contributor.authorvan Boxtel MPJ
dc.contributor.authorLipnicki DM
dc.contributor.authorCrawford JD
dc.contributor.authorCastro-Costa E
dc.contributor.authorLima-Costa MF
dc.contributor.authorBlay SL
dc.contributor.authorShifu X
dc.contributor.authorWang T
dc.contributor.authorYue L
dc.contributor.authorLipton RB
dc.contributor.authorKatz MJ
dc.contributor.authorDerby CA
dc.contributor.authorGuerchet M
dc.contributor.authorPreux P-M
dc.contributor.authorMbelesso P
dc.contributor.authorNorton J
dc.contributor.authorRitchie K
dc.contributor.authorSkoog I
dc.contributor.authorNajar J
dc.contributor.authorSterner TR
dc.contributor.authorScarmeas N
dc.contributor.authorYannakoulia M
dc.contributor.authorDardiotis T
dc.contributor.authorRolandi E
dc.contributor.authorDavin A
dc.contributor.authorRossi M
dc.contributor.authorGureje O
dc.contributor.authorOjagbemi A
dc.contributor.authorBello T
dc.contributor.authorKim KW
dc.contributor.authorHan JW
dc.contributor.authorOh DJ
dc.contributor.authorTrompet S
dc.contributor.authorGussekloo J
dc.contributor.authorRiedel-Heller SG
dc.contributor.authorRöhr S
dc.contributor.authorPabst A
dc.contributor.authorShahar S
dc.contributor.authorRivan NFM
dc.contributor.authorSingh DKA
dc.contributor.authorJacobsen E
dc.contributor.authorGanguli M
dc.contributor.authorHughes T
dc.contributor.authorHaan M
dc.contributor.authorAiello AE
dc.contributor.authorDing D
dc.contributor.authorZhao Q
dc.contributor.authorXiao Z
dc.contributor.authorNarazaki K
dc.contributor.authorChen T
dc.contributor.authorChen S
dc.contributor.authorNg TP
dc.contributor.authorGwee X
dc.contributor.authorGao Q
dc.contributor.authorBrodaty H
dc.contributor.authorTrollor J
dc.contributor.authorKochan N
dc.contributor.authorLobo A
dc.contributor.authorSantabárbara J
dc.contributor.authorGracia-Garcia P
dc.contributor.authorSachdev PS
dc.contributor.authorDeckers K
dc.contributor.authorfor Cohort Studies of Memory in an International Consortium (COSMIC)
dc.coverage.spatialUnited States
dc.date.accessioned2024-09-08T20:50:10Z
dc.date.available2024-09-08T20:50:10Z
dc.date.issued2024-06-16
dc.description.abstractINTRODUCTION: The LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dementia is moderated by geographical location or sociodemographic characteristics. METHODS: We combined data from 21 prospective cohorts across six continents (N = 31,680) and conducted cohort-specific Cox proportional hazard regression analyses in a two-step individual participant data meta-analysis. RESULTS: A one-standard-deviation increase in LIBRA score was associated with a 21% higher risk for dementia. The association was stronger for Asian cohorts compared to European cohorts, and for individuals aged ≤75 years (vs older), though only within the first 5 years of follow-up. No interactions with sex, education, or socioeconomic position were observed. DISCUSSION: Modifiable risk and protective factors appear relevant for dementia risk reduction across diverse geographical and sociodemographic groups. HIGHLIGHTS: - A two-step individual participant data meta-analysis was conducted. - This was done at a global scale using data from 21 ethno-regionally diverse cohorts. - The association between a modifiable dementia risk score and dementia was examined. - The association was modified by geographical region and age at baseline. - Yet, modifiable dementia risk and protective factors appear relevant in all investigated groups and regions.
dc.description.confidentialfalse
dc.edition.editionJune 2024
dc.format.pagination3972-3986
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/38676366
dc.identifier.citationVan Asbroeck S, Köhler S, van Boxtel MPJ, Lipnicki DM, Crawford JD, Castro-Costa E, Lima-Costa MF, Blay SL, Shifu X, Wang T, Yue L, Lipton RB, Katz MJ, Derby CA, Guerchet M, Preux P-M, Mbelesso P, Norton J, Ritchie K, Skoog I, Najar J, Sterner TR, Scarmeas N, Yannakoulia M, Dardiotis T, Rolandi E, Davin A, Rossi M, Gureje O, Ojagbemi A, Bello T, Kim KW, Han JW, Oh DJ, Trompet S, Gussekloo J, Riedel-Heller SG, Röhr S, Pabst A, Shahar S, Rivan NFM, Singh DKA, Jacobsen E, Ganguli M, Hughes T, Haan M, Aiello AE, Ding D, Zhao Q, Xiao Z, Narazaki K, Chen T, Chen S, Ng TP, Gwee X, Gao Q, Brodaty H, Trollor J, Kochan N, Lobo A, Santabárbara J, Gracia-Garcia P, Sachdev PS, Deckers K, for Cohort Studies of Memory in an International Consortium (COSMIC) . (2024). [Not Available].. Alzheimers Dement. 20. 6. (pp. 3972-3986).
dc.identifier.doi10.1002/alz.13846
dc.identifier.eissn1552-5279
dc.identifier.elements-typejournal-article
dc.identifier.issn1552-5260
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71422
dc.languageita
dc.publisherWiley Periodicals LLC on behalf of Alzheimer's Association
dc.publisher.urihttps://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13846
dc.relation.isPartOfAlzheimers Dement
dc.rights(c) The author/sen
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectage
dc.subjectdementia
dc.subjectdementia risk reduction
dc.subjecteducation
dc.subjecteffect modification
dc.subjectethnicity
dc.subjectindividual participant data meta‐analysis
dc.subjectinteraction
dc.subjectlifestyle
dc.subjectprimary prevention
dc.subjectregion
dc.subjectrisk factor
dc.subjectrisk personalization
dc.subjectsex
dc.subjectsocioeconomic
dc.subjectHumans
dc.subjectDementia
dc.subjectLife Style
dc.subjectMale
dc.subjectFemale
dc.subjectRisk Factors
dc.subjectAged
dc.subjectProspective Studies
dc.subjectIncidence
dc.titleLifestyle and incident dementia: A COSMIC individual participant data meta-analysis
dc.typeJournal article
pubs.elements-id92602
pubs.organisational-groupOther
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