Comorbidity and temporal associations between mental disorders among college students in the world mental health international college student initiative

dc.citation.volume351
dc.contributor.authorRoest AM
dc.contributor.authorde Vries YA
dc.contributor.authorPozuelo JR
dc.contributor.authorPetukhova MV
dc.contributor.authorLee S
dc.contributor.authorSampson NA
dc.contributor.authorAlbor Y
dc.contributor.authorAlhadi AN
dc.contributor.authorAlonso J
dc.contributor.authorAl-Saud N
dc.contributor.authorAltwaijri Y
dc.contributor.authorAndersson C
dc.contributor.authorAtwoli L
dc.contributor.authorAuerbach RP
dc.contributor.authorMuaka CA
dc.contributor.authorBáez-Mansur PM
dc.contributor.authorBallester L
dc.contributor.authorBantjes J
dc.contributor.authorBaumeister H
dc.contributor.authorBendtsen M
dc.contributor.authorBenjet C
dc.contributor.authorBerman AH
dc.contributor.authorBruffaerts R
dc.contributor.authorCarrasco P
dc.contributor.authorChan SCN
dc.contributor.authorCohut I
dc.contributor.authorCouder MAC
dc.contributor.authorCrockett MA
dc.contributor.authorCuijpers P
dc.contributor.authorDavid OA
dc.contributor.authorDong D
dc.contributor.authorEbert DD
dc.contributor.authorGaete J
dc.contributor.authorForero CG
dc.contributor.authorGili M
dc.contributor.authorGutiérrez-García R
dc.contributor.authorHaro JM
dc.contributor.authorHasking P
dc.contributor.authorHunt X
dc.contributor.authorHusky MM
dc.contributor.authorJaguga F
dc.contributor.authorLanger ÁI
dc.contributor.authorLéniz I
dc.contributor.authorLiu Y
dc.contributor.authorMac-Ginty S
dc.contributor.authorMartínez V
dc.contributor.authorMcLafferty M
dc.contributor.authorMiranda A
dc.contributor.authorMonroy-Velasco IR
dc.contributor.authorMurray EK
dc.contributor.authorMusyoka CM
dc.contributor.authorNedelcea C
dc.contributor.authorNúñez D
dc.contributor.authorO'Neill SM
dc.contributor.authorPiqueras JA
dc.contributor.authorPopescu CA
dc.contributor.authorPrescivalli AP
dc.contributor.authorRapsey C
dc.contributor.authorRobinson K
dc.contributor.authorRodriguez-Jimenez T
dc.contributor.authorSaal W
dc.contributor.authorSiu O-L
dc.contributor.authorStein DJ
dc.contributor.authorStruijs SY
dc.contributor.authorTomoiaga CT
dc.contributor.authorValdés-García KP
dc.contributor.authorVargas-Contreras E
dc.contributor.authorVigo DV
dc.contributor.authorWang AY
dc.contributor.authorWong SYS
dc.contributor.authorKessler RC
dc.contributor.authorWorld Mental Health International College Student collaborators
dc.date.accessioned2025-07-18T02:26:04Z
dc.date.available2025-07-18T02:26:04Z
dc.date.issued2025-09-01
dc.description.abstractBackground: Mental disorders are highly prevalent among students worldwide. This study aims to examine comorbidity and temporal associations between mental disorders among students. Methods: The study included 72,288 students from 18 countries as part of the World Mental Health International College Student (WMH-ICS) Initiative, with cross-sectional data collected between 2017 and 2023. Screening for common DSM-5 disorders was conducted using validated screening measures. Latent variables were examined using exploratory principal axis factor analysis on a correlation matrix among the lifetime mental disorders. Based on age-of-onset information, multivariable poisson regression models were used to examine associations of prior disorders with the first onset of other disorders. Results: 27.0 % of students screened positive for only one lifetime disorder, 17.1 % for two, 10.9 % for three, and 10.6 % for 4+ disorders. In the factor analysis, three latent variables were found, comprising: internalizing disorders (generalized anxiety disorder, major depressive episode, post-traumatic stress disorder, and panic disorder), substance use disorders (drug use disorder and alcohol use disorder), and externalizing disorders (attention deficit/hyperactivity disorder and mania/hypomania). Prior internalizing and externalizing disorders were associated with the subsequent first onset of all other disorders with risk ratios ranging from 1.5–7.5. Substance use disorders were less consistently associated with the subsequent first onset of other disorders, but alcohol use disorder was associated with the first onset of drug use disorder and vice versa. Conclusions: Mental disorder comorbidity is common among students, and students with disorders across the internalizing and externalizing spectrum have an increased risk of future mental disorder comorbidities.
dc.description.confidentialfalse
dc.edition.editionSeptember 2025
dc.identifier.citationRoest AM, de Vries YA, Pozuelo JR, Petukhova MV, Lee S, Sampson NA, Albor Y, Alhadi AN, Alonso J, Al-Saud N, Altwaijri Y, Andersson C, Atwoli L, Auerbach RP, Muaka CA, Báez-Mansur PM, Ballester L, Bantjes J, Baumeister H, Bendtsen M, Benjet C, Berman AH, Bruffaerts R, Carrasco P, Chan SCN, Cohut I, Couder MACD, Crockett MA, Cuijpers P, David OA, Dong D, Ebert DD, Gaete J, Forero CG, Gili M, Gutiérrez-García R, Haro JM, Hasking P, Hunt X, Husky MM, Jaguga F, Langer ÁI, Léniz I, Liu Y, Mac-Ginty S, Martínez V, McLafferty M, Miranda A, Monroy-Velasco IR, Murray EK, Musyoka CM, Nedelcea C, Núñez D, O'Neill SM, Piqueras JA, Popescu CA, Prescivalli AP, Rapsey C, Robinson K, Rodriguez-Jimenez T, Saal W, Siu OL, Stein DJ, Struijs SY, Tomoiaga CT, Valdés-García KP, Vargas-Contreras E, Vigo DV, Wang AY, Wong SYS, Kessler RC, Boffo M, Borges G, Breet E, Cristóbal-Narvaez P, Cruz-Hernández S, Garnefski N, Uribe PCH, Hurks P, Jacobs K, Jansen L, Jiménez-Pérez AL, Klinkenberg EF, Kraaij V, Lima RA, Lochner C, Owuor FO, Medina-Mora ME, Mori T, Munro L, Munthali RJ, Nooij J, Paz-Peréz MA, Rebagliato M, Remmerswaal D, Roca M, Salemink E, van der Heijde C, Voorspoels W, Wiers RW. (2025). Comorbidity and temporal associations between mental disorders among college students in the world mental health international college student initiative. Psychiatry Research. 351.
dc.identifier.doi10.1016/j.psychres.2025.116605
dc.identifier.eissn1872-7123
dc.identifier.elements-typejournal-article
dc.identifier.issn0165-1781
dc.identifier.number116605
dc.identifier.piiS0165178125002537
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/73209
dc.languageEnglish
dc.publisherElsevier B V
dc.publisher.urihttps://www.sciencedirect.com/science/article/pii/S0165178125002537
dc.relation.isPartOfPsychiatry Research
dc.rights(c) 2025 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectInternalizing
dc.subjectExternalizing
dc.subjectComorbidity
dc.subjectCollege students
dc.subjectSubstance use disorders
dc.titleComorbidity and temporal associations between mental disorders among college students in the world mental health international college student initiative
dc.typeJournal article
pubs.elements-id501562
pubs.organisational-groupOther
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