Starch Wars-New Episodes of the Saga. Changes in Regulations on Hydroxyethyl Starch in the European Union

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dc.citation.volume5
dc.contributor.authorAdamik K-N
dc.contributor.authorYozova ID
dc.date.available2019-01-18
dc.date.available2018-12-14
dc.date.issued18/01/2019
dc.description.abstractAfter a safety review of hydroxyethyl starch (HES) solutions in 2013, restrictions on the use of HES were introduced in the European Union (EU) to reduce the risk of kidney injury and death in certain patient populations. Similar restrictions were introduced by the Food and Drug Administration in the United States and other countries. In October 2017, a second safety review of HES solutions was triggered by the European pharmacovigilance authorities based on a request by the Swedish Medical Products Agency to completely suspend HES. After several meetings and repeated evaluations, the recommendation to ban HES was ultimately not endorsed by the responsible committee; however, there was a vote for more restricted access to the drug and rigorous monitoring of policy adherence. This review delineates developments in the European pharmacovigilance risk assessment of HES solutions between 2013 and 2018. In addition, the divergent experts' opinions and the controversy surrounding this official assessment are described. As the new decisions might influence the availability of HES products for veterinary patients, potential alternatives to HES solutions, such as albumin solutions and gelatin, are briefly discussed.
dc.description.publication-statusPublished
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000467488900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef
dc.identifierARTN 336
dc.identifier.citationFRONTIERS IN VETERINARY SCIENCE, 2019, 5
dc.identifier.doi10.3389/fvets.2018.00336
dc.identifier.elements-id419751
dc.identifier.harvestedMassey_Dark
dc.identifier.issn2297-1769
dc.identifier.urihttps://hdl.handle.net/10179/16796
dc.publisherFrontiers Media SA
dc.relation.isPartOfFRONTIERS IN VETERINARY SCIENCE
dc.relation.urihttps://www.frontiersin.org/articles/10.3389/fvets.2018.00336/full
dc.subjectgelatin
dc.subjectdextran
dc.subjectplasma expanders
dc.subjectpharmacovigilance
dc.subjectsynthetic colloids
dc.subjectfluid therapy
dc.subjectEuropean Medicines Agency
dc.subjectFood and Drug Administration
dc.subject.anzsrc0707 Veterinary Sciences
dc.titleStarch Wars-New Episodes of the Saga. Changes in Regulations on Hydroxyethyl Starch in the European Union
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Sciences
pubs.organisational-group/Massey University/College of Sciences/School of Veterinary Science
pubs.organisational-group/Massey University/College of Sciences/School of Veterinary Science/Veterinary Clinic & Teaching Hospital
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