Ovine FABP4 Variation and Its Association With Flystrike Susceptibility

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dc.citation.volume12
dc.contributor.authorBurrows LER
dc.contributor.authorZhou H
dc.contributor.authorFrampton CMA
dc.contributor.authorForrest RHJ
dc.contributor.authorHickford JGH
dc.contributor.editorSu R
dc.date.accessioned2024-02-23T00:08:45Z
dc.date.accessioned2024-07-25T06:51:01Z
dc.date.available2021-06-15
dc.date.available2024-02-23T00:08:45Z
dc.date.available2024-07-25T06:51:01Z
dc.date.issued2021-06-15
dc.description.abstractFlystrike is a major cost and a welfare issue for the New Zealand sheep industry. There are several factors that can predispose sheep to flystrike, such as having fleecerot, a urine-stained breech, and “dags” (an accumulation of fecal matter in the wool of the breech). The FABP4 gene (FABP4) has been associated with variation in ovine fleecerot resistance, with a strong genetic correlation existing between fleecerot and flystrike occurrence. In this study, blood samples were collected from sheep with and without flystrike for DNA typing. PCR-SSCP analyses were used to genotype two regions of ovine FABP4. Sheep with the A1 variant of FABP4 were found to be less likely (odds ratio 0.689, P = 0.014) to have flystrike than those without A1. The likelihood of flystrike occurrence decreased as copy number of A1 increased (odds ratio 0.695, P = 0.006). This suggests that FABP4 might be a candidate gene for flystrike resilience in sheep, although further research is required to verify this association.
dc.description.confidentialfalse
dc.edition.editionJune 2021
dc.identifier.citationBurrows LER, Zhou H, Frampton CMA, Forrest RHJ, Hickford JGH. (2021). Ovine FABP4 Variation and Its Association With Flystrike Susceptibility. Frontiers in Genetics. 12.
dc.identifier.doi10.3389/fgene.2021.675305
dc.identifier.eissn1664-8021
dc.identifier.elements-typejournal-article
dc.identifier.number675305.
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71006
dc.languageEnglish
dc.publisherFrontiers Media S.A.
dc.publisher.urihttps://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2021.675305/full
dc.relation.isPartOfFrontiers in Genetics
dc.subjectFABP4
dc.subjectflystrike
dc.subjectPCR-SSCP
dc.subjectsheep
dc.subjectvariation
dc.titleOvine FABP4 Variation and Its Association With Flystrike Susceptibility
dc.typeJournal article
pubs.elements-id486503
pubs.organisational-groupOther
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