Reconstruction of gene innovation associated with major evolutionary transitions in the kingdom Fungi

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dc.citation.issue1
dc.citation.volume20
dc.contributor.authorWu B
dc.contributor.authorHao W
dc.contributor.authorCox MP
dc.coverage.spatialEngland
dc.date.accessioned2025-03-27T22:05:11Z
dc.date.available2025-03-27T22:05:11Z
dc.date.issued2022-12
dc.description.abstractBACKGROUND: Fungi exhibit astonishing diversity with multiple major phenotypic transitions over the kingdom's evolutionary history. As part of this process, fungi developed hyphae, adapted to land environments (terrestrialization), and innovated their sexual structures. These changes also helped fungi establish ecological relationships with other organisms (animals and plants), but the genomic basis of these changes remains largely unknown. RESULTS: By systematically analyzing 304 genomes from all major fungal groups, together with a broad range of eukaryotic outgroups, we have identified 188 novel orthogroups associated with major changes during the evolution of fungi. Functional annotations suggest that many of these orthogroups were involved in the formation of key trait innovations in extant fungi and are functionally connected. These innovations include components for cell wall formation, functioning of the spindle pole body, polarisome formation, hyphal growth, and mating group signaling. Innovation of mitochondria-localized proteins occurred widely during fungal transitions, indicating their previously unrecognized importance. We also find that prokaryote-derived horizontal gene transfer provided a small source of evolutionary novelty with such genes involved in key metabolic pathways. CONCLUSIONS: The overall picture is one of a relatively small number of novel genes appearing at major evolutionary transitions in the phylogeny of fungi, with most arising de novo and horizontal gene transfer providing only a small additional source of evolutionary novelty. Our findings contribute to an increasingly detailed portrait of the gene families that define fungal phyla and underpin core features of extant fungi.
dc.description.confidentialfalse
dc.edition.editionDecember 2022
dc.format.pagination144-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/35706021
dc.identifier.citationWu B, Hao W, Cox MP. (2022). Reconstruction of gene innovation associated with major evolutionary transitions in the kingdom Fungi.. BMC Biol. 20. 1. (pp. 144-).
dc.identifier.doi10.1186/s12915-022-01346-8
dc.identifier.eissn1741-7007
dc.identifier.elements-typejournal-article
dc.identifier.issn1741-7007
dc.identifier.number144
dc.identifier.pii10.1186/s12915-022-01346-8
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/72702
dc.languageeng
dc.publisherBioMed Central Ltd
dc.publisher.urihttps://bmcbiol.biomedcentral.com/articles/10.1186/s12915-022-01346-8
dc.relation.isPartOfBMC Biol
dc.rights(c) 2022 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectFungi
dc.subjectGene gain
dc.subjectHorizontal transfer
dc.subjectMitochondria
dc.subjectTrait transitions
dc.subjectAnimals
dc.subjectEvolution, Molecular
dc.subjectFungi
dc.subjectGene Transfer, Horizontal
dc.subjectPhylogeny
dc.subjectPlants
dc.titleReconstruction of gene innovation associated with major evolutionary transitions in the kingdom Fungi
dc.typeJournal article
pubs.elements-id454035
pubs.organisational-groupOther
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