Sex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium.

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dc.citation.issue8
dc.citation.volume19
dc.contributor.authorGong J
dc.contributor.authorHarris K
dc.contributor.authorLipnicki DM
dc.contributor.authorCastro-Costa E
dc.contributor.authorLima-Costa MF
dc.contributor.authorDiniz BS
dc.contributor.authorXiao S
dc.contributor.authorLipton RB
dc.contributor.authorKatz MJ
dc.contributor.authorWang C
dc.contributor.authorPreux P-M
dc.contributor.authorGuerchet M
dc.contributor.authorGbessemehlan A
dc.contributor.authorRitchie K
dc.contributor.authorAncelin M-L
dc.contributor.authorSkoog I
dc.contributor.authorNajar J
dc.contributor.authorSterner TR
dc.contributor.authorScarmeas N
dc.contributor.authorYannakoulia M
dc.contributor.authorKosmidis MH
dc.contributor.authorGuaita A
dc.contributor.authorRolandi E
dc.contributor.authorDavin A
dc.contributor.authorGureje O
dc.contributor.authorTrompet S
dc.contributor.authorGussekloo J
dc.contributor.authorRiedel-Heller S
dc.contributor.authorPabst A
dc.contributor.authorRöhr S
dc.contributor.authorShahar S
dc.contributor.authorSingh DKA
dc.contributor.authorRivan NFM
dc.contributor.authorBoxtel MV
dc.contributor.authorKöhler S
dc.contributor.authorGanguli M
dc.contributor.authorChang C-C
dc.contributor.authorJacobsen E
dc.contributor.authorHaan M
dc.contributor.authorDing D
dc.contributor.authorZhao Q
dc.contributor.authorNarazaki K
dc.contributor.authorChen T
dc.contributor.authorChen S
dc.contributor.authorNg TP
dc.contributor.authorGwee X
dc.contributor.authorNumbers K
dc.contributor.authorMather KA
dc.contributor.authorScazufca M
dc.contributor.authorLobo A
dc.contributor.authorDe-la-Cámara C
dc.contributor.authorLobo E
dc.contributor.authorSachdev PS
dc.contributor.authorBrodaty H
dc.contributor.authorHackett ML
dc.contributor.authorPeters SAE
dc.contributor.authorWoodward M
dc.coverage.spatialUnited States
dc.date.accessioned2024-05-15T02:10:22Z
dc.date.available2024-05-15T02:10:22Z
dc.date.issued2023-08-01
dc.description.abstractINTRODUCTION: Sex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno-regional groups. METHODS: A total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data meta-analysis. Sex-specific hazard ratios (HRs), and women-to-men ratio of hazard ratios (RHRs) for associations between RFs and all-cause dementia were derived from mixed-effect Cox models. RESULTS: Incident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in low- and lower-middle-income economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs. DISCUSSION: Dementia risk was higher in women than men, with possible variations by country-level income settings, but most RFs appear to work similarly in women and men.
dc.description.confidentialfalse
dc.edition.editionAugust 2023
dc.format.pagination3365-3378
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/36790027
dc.identifier.citationGong J, Harris K, Lipnicki DM, Castro-Costa E, Lima-Costa MF, Diniz BS, Xiao S, Lipton RB, Katz MJ, Wang C, Preux P-M, Guerchet M, Gbessemehlan A, Ritchie K, Ancelin M-L, Skoog I, Najar J, Sterner TR, Scarmeas N, Yannakoulia M, Kosmidis MH, Guaita A, Rolandi E, Davin A, Gureje O, Trompet S, Gussekloo J, Riedel-Heller S, Pabst A, Röhr S, Shahar S, Singh DKA, Rivan NFM, Boxtel MV, Köhler S, Ganguli M, Chang C-C, Jacobsen E, Haan M, Ding D, Zhao Q, Xiao Z, Narazaki K, Chen T, Chen S, Ng TP, Gwee X, Numbers K, Mather KA, Scazufca M, Lobo A, De-la-Cámara C, Lobo E, Sachdev PS, Brodaty H, Hackett ML, Peters SAE, Woodward M, Cohort Studies of Memory in an International Consortium (COSMIC) . (2023). Sex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium.. Alzheimers Dement. 19. 8. (pp. 3365-3378).
dc.identifier.doi10.1002/alz.12962
dc.identifier.eissn1552-5279
dc.identifier.elements-typejournal-article
dc.identifier.issn1552-5260
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/69566
dc.languageeng
dc.publisherJohn Wiley and Sons, Inc.
dc.publisher.urihttps://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12962
dc.relation.isPartOfAlzheimers Dement
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectdata harmonization
dc.subjectdementia
dc.subjectdiversity
dc.subjectrisk factor
dc.subjectsex difference
dc.subjectHumans
dc.subjectMale
dc.subjectFemale
dc.subjectSex Characteristics
dc.subjectRisk Factors
dc.subjectAlcohol Drinking
dc.subjectDementia
dc.subjectSex Factors
dc.titleSex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium.
dc.typeJournal article
pubs.elements-id459885
pubs.organisational-groupOther
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