Gluten Induces Subtle Histological Changes in Duodenal Mucosa of Patients with Non-Coeliac Gluten Sensitivity: A Multicentre Study

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dc.citation.issue12
dc.citation.volume14
dc.contributor.authorRostami K
dc.contributor.authorEnsari A
dc.contributor.authorMarsh MN
dc.contributor.authorSrivastava A
dc.contributor.authorVillanacci V
dc.contributor.authorCarroccio A
dc.contributor.authorAsadzadeh Aghdaei H
dc.contributor.authorBai JC
dc.contributor.authorBassotti G
dc.contributor.authorBecheanu G
dc.contributor.authorBell P
dc.contributor.authorDi Bella C
dc.contributor.authorBozzola AM
dc.contributor.authorCadei M
dc.contributor.authorCasella G
dc.contributor.authorCatassi C
dc.contributor.authorCiacci C
dc.contributor.authorApostol Ciobanu DG
dc.contributor.authorCross SS
dc.contributor.authorDanciu M
dc.contributor.authorDas P
dc.contributor.authorDel Sordo R
dc.contributor.authorDrage M
dc.contributor.authorElli L
dc.contributor.authorFasano A
dc.contributor.authorFlorena AM
dc.contributor.authorFusco N
dc.contributor.authorGoing JJ
dc.contributor.authorGuandalini S
dc.contributor.authorHagen CE
dc.contributor.authorHayman DTS
dc.contributor.authorIshaq S
dc.contributor.authorJericho H
dc.contributor.authorJohncilla M
dc.contributor.authorJohnson M
dc.contributor.authorKaukinen K
dc.contributor.authorLevene A
dc.contributor.authorLiptrot S
dc.contributor.authorLu L
dc.contributor.authorMakharia GK
dc.contributor.authorMathews S
dc.contributor.authorMazzarella G
dc.contributor.authorMaxim R
dc.contributor.authorLa Win Myint K
dc.contributor.authorMohaghegh-Shalmani H
dc.contributor.authorMoradi A
dc.contributor.authorMulder CJJ
dc.contributor.authorRay R
dc.contributor.authorRicci C
dc.contributor.authorRostami-Nejad M
dc.contributor.authorSapone A
dc.contributor.authorSanders DS
dc.contributor.authorTaavela J
dc.contributor.authorVolta U
dc.contributor.authorWalker M
dc.contributor.authorDerakhshan M
dc.contributor.editorWitteman B
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-01-31T22:21:15Z
dc.date.accessioned2024-07-25T06:36:51Z
dc.date.available2022-06-15
dc.date.available2024-01-31T22:21:15Z
dc.date.available2024-07-25T06:36:51Z
dc.date.issued2022-06-15
dc.description.abstractBackground: Histological changes induced by gluten in the duodenal mucosa of patients with non-coeliac gluten sensitivity (NCGS) are poorly defined. Objectives: To evaluate the structural and inflammatory features of NCGS compared to controls and coeliac disease (CeD) with milder enteropathy (Marsh I-II). Methods: Well-oriented biopsies of 262 control cases with normal gastroscopy and histologic findings, 261 CeD, and 175 NCGS biopsies from 9 contributing countries were examined. Villus height (VH, in μm), crypt depth (CrD, in μm), villus-to-crypt ratios (VCR), IELs (intraepithelial lymphocytes/100 enterocytes), and other relevant histological, serologic, and demographic parameters were quantified. Results: The median VH in NCGS was significantly shorter (600, IQR: 400−705) than controls (900, IQR: 667−1112) (p < 0.001). NCGS patients with Marsh I-II had similar VH and VCR to CeD [465 µm (IQR: 390−620) vs. 427 µm (IQR: 348−569, p = 0·176)]. The VCR in NCGS with Marsh 0 was lower than controls (p < 0.001). The median IEL in NCGS with Marsh 0 was higher than controls (23.0 vs. 13.7, p < 0.001). To distinguish Marsh 0 NCGS from controls, an IEL cut-off of 14 showed 79% sensitivity and 55% specificity. IEL densities in Marsh I-II NCGS and CeD groups were similar. Conclusion: NCGS duodenal mucosa exhibits distinctive changes consistent with an intestinal response to luminal antigens, even at the Marsh 0 stage of villus architecture.
dc.description.confidentialfalse
dc.edition.editionJune 2022
dc.format.pagination2487-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/35745217
dc.identifier.citationRostami K, Ensari A, Marsh MN, Srivastava A, Villanacci V, Carroccio A, Asadzadeh Aghdaei H, Bai JC, Bassotti G, Becheanu G, Bell P, Di Bella C, Bozzola AM, Cadei M, Casella G, Catassi C, Ciacci C, Apostol Ciobanu DG, Cross SS, Danciu M, Das P, Del Sordo R, Drage M, Elli L, Fasano A, Florena AM, Fusco N, Going JJ, Guandalini S, Hagen CE, Hayman DTS, Ishaq S, Jericho H, Johncilla M, Johnson M, Kaukinen K, Levene A, Liptrot S, Lu L, Makharia GK, Mathews S, Mazzarella G, Maxim R, La Win Myint K, Mohaghegh-Shalmani H, Moradi A, Mulder CJJ, Ray R, Ricci C, Rostami-Nejad M, Sapone A, Sanders DS, Taavela J, Volta U, Walker M, Derakhshan M. (2022). Gluten Induces Subtle Histological Changes in Duodenal Mucosa of Patients with Non-Coeliac Gluten Sensitivity: A Multicentre Study.. Nutrients. 14. 12. (pp. 2487-).
dc.identifier.doi10.3390/nu14122487
dc.identifier.eissn2072-6643
dc.identifier.elements-typejournal-article
dc.identifier.issn2072-6643
dc.identifier.number2487
dc.identifier.piinu14122487
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70542
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2072-6643/14/12/2487
dc.relation.isPartOfNutrients
dc.rights(c) The author/sen
dc.rights.licenseCC BY 4.0en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectcoeliac disease
dc.subjecthistology
dc.subjectnon-coeliac gluten sensitivity
dc.subjectnormal mucosa
dc.subjectBiopsy
dc.subjectCeliac Disease
dc.subjectDiet, Gluten-Free
dc.subjectDuodenum
dc.subjectGlutens
dc.subjectHumans
dc.subjectIntestinal Mucosa
dc.titleGluten Induces Subtle Histological Changes in Duodenal Mucosa of Patients with Non-Coeliac Gluten Sensitivity: A Multicentre Study
dc.typeJournal article
pubs.elements-id454143
pubs.organisational-groupOther
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