Effects of halothane on the electroencephalogram of the chicken

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dc.citation.issue2
dc.citation.volume4
dc.contributor.authorMcIlhone AE
dc.contributor.authorBeausoleil NJ
dc.contributor.authorKells NJ
dc.contributor.authorJohnson CB
dc.contributor.authorMellor DJ
dc.date.available2018-05
dc.date.issued2018-05-15
dc.description.abstractLittle is known about the effects of inhalant anaesthetics on the avian electroencephalogram (EEG). The effects of halothane on the avian EEG are of interest, as this agent has been widely used to study nociception and analgesia in mammals. The objective of this study was to characterize the effects of halothane anaesthesia on the EEG of the chicken. Twelve female Hyline Brown chickens aged 8-10 weeks were anaesthetized with halothane in oxygen. For each bird, anaesthesia was progressively increased from 1-1.5 to 2 times the Minimum Anesthetic Concentration (MAC), then progressively decreased again. At each concentration, a sample of EEG was recorded after a 10-min stabilization period. The mean Total Power (PTOT ), Median Frequency (F50) and 95% Spectral Edge Frequency (F95) were calculated at each halothane MAC, along with the Burst Suppression Ratio (BSR). Burst suppression was rare and BSR did not differ between halothane concentrations. Increasing halothane concentration from 1 to 2 MAC resulted in a decrease in F50 and increase in PTOT , while F95 increased when MAC was reduced from 1.5 to 1. The results indicate dose-dependent spectral EEG changes consistent with deepening anaesthesia in response to increasing halothane MAC. As burst suppression was rare, even at 1.5 or 2 times MAC, halothane may be a suitable anaesthetic agent for use in future studies exploring EEG activity in anaesthetized birds.
dc.description.publication-statusPublished
dc.format.extent98 - 105
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000433597500004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef
dc.identifier.citationVETERINARY MEDICINE AND SCIENCE, 2018, 4 (2), pp. 98 - 105
dc.identifier.doi10.1002/vms3.91
dc.identifier.elements-id410502
dc.identifier.harvestedMassey_Dark
dc.identifier.issn2053-1095
dc.publisherJohn Wiley and Sons, Ltd
dc.relation.isPartOfVETERINARY MEDICINE AND SCIENCE
dc.rights© 2018 The Authors CC BY 4.0
dc.subjectEEG
dc.subjectchicken
dc.subjectanaesthesia
dc.subjecthalothane
dc.subjectburst suppression
dc.titleEffects of halothane on the electroencephalogram of the chicken
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Sciences
pubs.organisational-group/Massey University/College of Sciences/School of Veterinary Science
pubs.organisational-group/Massey University/Other
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