The fecal microbiotas of women of Pacific and New Zealand European ethnicities are characterized by distinctive enterotypes that reflect dietary intakes and fecal water content.

Simple item page
dc.citation.issue1
dc.citation.volume15
dc.contributor.authorRenall N
dc.contributor.authorLawley B
dc.contributor.authorVatanen T
dc.contributor.authorMerz B
dc.contributor.authorDouwes J
dc.contributor.authorCorbin M
dc.contributor.authorTe Morenga L
dc.contributor.authorKruger R
dc.contributor.authorBreier BH
dc.contributor.authorTannock GW
dc.coverage.spatialUnited States
dc.date.accessioned2024-05-23T21:52:13Z
dc.date.available2024-05-23T21:52:13Z
dc.date.issued2023-02-17
dc.description.abstractObesity is a complex, multifactorial condition that is an important risk factor for noncommunicable diseases including cardiovascular disease and type 2 diabetes. While prevention and management require a healthy and energy balanced diet and adequate physical activity, the taxonomic composition and functional attributes of the colonic microbiota may have a supplementary role in the development of obesity. The taxonomic composition and metabolic capacity of the fecal microbiota of 286 women, resident in Auckland New Zealand, was determined by metagenomic analysis. Associations with BMI (obese, nonobese), body fat composition, and ethnicity (Pacific, n = 125; NZ European women [NZE], n = 161) were assessed using regression analyses. The fecal microbiotas were characterized by the presence of three distinctive enterotypes, with enterotype 1 represented in both Pacific and NZE women (39 and 61%, respectively), enterotype 2 mainly in Pacific women (84 and 16%) and enterotype 3 mainly in NZE women (13 and 87%). Enterotype 1 was characterized mainly by the relative abundances of butyrate producing species, Eubacterium rectale and Faecalibacterium prausnitzii, enterotype 2 by the relative abundances of lactic acid producing species, Bifidobacterium adolescentis, Bifidobacterium bifidum, and Lactobacillus ruminis, and enterotype 3 by the relative abundances of Subdoligranulum sp., Akkermansia muciniphila, Ruminococcus bromii, and Methanobrevibacter smithii. Enterotypes were also associated with BMI, visceral fat %, and blood cholesterol. Habitual food group intake was estimated using a 5 day nonconsecutive estimated food record and a 30 day, 220 item semi-quantitative Food Frequency Questionnaire. Higher intake of 'egg' and 'dairy' products was associated with enterotype 3, whereas 'non-starchy vegetables', 'nuts and seeds' and 'plant-based fats' were positively associated with enterotype 1. In contrast, these same food groups were inversely associated with enterotype 2. Fecal water content, as a proxy for stool consistency/colonic transit time, was associated with microbiota taxonomic composition and gene pools reflective of particular bacterial biochemical pathways. The fecal microbiotas of women of Pacific and New Zealand European ethnicities are characterized by distinctive enterotypes, most likely due to differential dietary intake and fecal consistency/colonic transit time. These parameters need to be considered in future analyses of human fecal microbiotas.
dc.description.confidentialfalse
dc.format.pagination2178801-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/36799472
dc.identifier.citationRenall N, Lawley B, Vatanen T, Merz B, Douwes J, Corbin M, Te Morenga L, Kruger R, Breier BH, Tannock GW. (2023). The fecal microbiotas of women of Pacific and New Zealand European ethnicities are characterized by distinctive enterotypes that reflect dietary intakes and fecal water content.. Gut Microbes. 15. 1. (pp. 2178801-).
dc.identifier.doi10.1080/19490976.2023.2178801
dc.identifier.eissn1949-0984
dc.identifier.elements-typejournal-article
dc.identifier.issn1949-0976
dc.identifier.number2178801
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/69652
dc.languageeng
dc.publisherTaylor and Francis Groups
dc.publisher.urihttps://www.tandfonline.com/doi/full/10.1080/19490976.2023.2178801
dc.relation.isPartOfGut Microbes
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.en
dc.subjectFecal microbiota
dc.subjectdietary intake
dc.subjectenterotypes
dc.subjectfecal water content
dc.subjectobesity
dc.subjectHumans
dc.subjectFemale
dc.subjectEthnicity
dc.subjectDiabetes Mellitus, Type 2
dc.subjectNew Zealand
dc.subjectGastrointestinal Microbiome
dc.subjectFeces
dc.subjectMicrobiota
dc.subjectObesity
dc.subjectEating
dc.titleThe fecal microbiotas of women of Pacific and New Zealand European ethnicities are characterized by distinctive enterotypes that reflect dietary intakes and fecal water content.
dc.typeJournal article
pubs.elements-id459846
pubs.organisational-groupCollege of Health
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
Published version.pdf
Size:
3.05 MB
Format:
Adobe Portable Document Format
Description:
459846 PDF.pdf
Download
Thumbnail Image
Name:
Evidence
Size:
345.02 KB
Format:
Unknown data format
Description:
kgmi_a_2178801_sm5275.zip
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
9.22 KB
Format:
Plain Text
Description:
Download
Collections
Journal Articles