Effects of Post-Exertional Malaise on Markers of Arterial Stiffness in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

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dc.citation.issue5
dc.citation.volume18
dc.contributor.authorBond J
dc.contributor.authorNielsen T
dc.contributor.authorHodges L
dc.coverage.spatialSwitzerland
dc.date.accessioned2023-08-22T03:21:42Z
dc.date.accessioned2023-09-04T01:41:35Z
dc.date.available2021-02-28
dc.date.available2023-08-22T03:21:42Z
dc.date.available2023-09-04T01:41:35Z
dc.date.issued2021-03
dc.date.updated2023-08-20T22:52:40Z
dc.descriptionCopyright: © 2021 by the authors.en_US
dc.description.abstractBackground: Evidence is emerging that individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may suffer from chronic vascular dysfunction as a result of illness-related oxidative stress and vascular inflammation. The study aimed to examine the impact of maximal-intensity aerobic exercise on vascular function 48 and 72 h into recovery. Methods: ME/CFS (n = 11) with gender and age-matched controls (n = 11) were randomly assigned to either a 48 h or 72 h protocol. Each participant had measures of brachial blood pressure, augmentation index (AIx75, standardized to 75 bpm) and carotid-radial pulse wave velocity (crPWV) taken. This was followed by a maximal incremental cycle exercise test. Resting measures were repeated 48 or 72 h later (depending on group allocation). Results: No significant differences were found when ME/CFS were directly compared to controls at baseline. During recovery, the 48 h control group experienced a significant 7.2% reduction in AIx75 from baseline measures (p < 0.05), while the matched ME/CFS experienced no change in AIx75. The 72 h ME/CFS group experienced a non-significant increase of 1.4% from baseline measures. The 48 h and 72 h ME/CFS groups both experienced non-significant improvements in crPWV (0.56 ms−1 and 1.55 ms−1, respectively). Conclusions: The findings suggest that those with ME/CFS may not experience exercise-induced vasodilation due to chronic vascular damage, which may be a contributor to the onset of post-exertional malaise (PEM).
dc.format.extent1-10
dc.identifierARTN 2366
dc.identifierijerph18052366
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/33671082
dc.identifier.citationBond J, Nielsen T, Hodges L. (2021). Effects of Post-Exertional Malaise on Markers of Arterial Stiffness in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.. Int J Environ Res Public Health. 18. 5. (pp. 1-10).
dc.identifier.doi10.3390/ijerph18052366
dc.identifier.eissn1660-4601
dc.identifier.elements-typejournal-article
dc.identifier.harvestedMassey_Dark
dc.identifier.issn1661-7827
dc.identifier.urihttp://hdl.handle.net/10179/19988
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.relation.isPartOfInt J Environ Res Public Health
dc.rightsCC BYen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectArterial Stiffness
dc.subjectChronic Fatigue Syndrome
dc.subjectMyalgic Encephalomyelitis
dc.subjectPost Exertional Malaise
dc.subjectExercise
dc.subjectExercise Test
dc.subjectFatigue Syndrome, Chronic
dc.subjectHumans
dc.subjectPulse Wave Analysis
dc.subjectVascular Stiffness
dc.titleEffects of Post-Exertional Malaise on Markers of Arterial Stiffness in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
dc.typeJournal article
pubs.elements-id440961
pubs.organisational-groupOther
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