Predictors and risks of body fat profiles in young New Zealand European, Māori and Pacific women: study protocol for the women’s EXPLORE study

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dc.citation.volume4
dc.contributor.authorKruger R
dc.contributor.authorShultz SP
dc.contributor.authorMcNaughton SA
dc.contributor.authorRussell AP
dc.contributor.authorFirestone RT
dc.contributor.authorGeorge L
dc.contributor.authorBeck KL
dc.contributor.authorConlon CA
dc.contributor.authorvon Hurst PR
dc.contributor.authorBreier B
dc.contributor.authorJayasinghe SN
dc.contributor.authorO Brien WJ
dc.contributor.authorJones B
dc.contributor.authorStonehouse W
dc.date.available2015-03-14
dc.date.available2015-03-03
dc.date.issued2015-12-01
dc.description.abstractBackground: Body mass index (BMI) (kg/m2) is used internationally to assess body mass or adiposity. However, BMI does not discriminate body fat content or distribution and may vary among ethnicities. Many women with normal BMI are considered healthy, but may have an unidentified “hidden fat” profile associated with higher metabolic disease risk. If only BMI is used to indicate healthy body size, it may fail to predict underlying risks of diseases of lifestyle among population subgroups with normal BMI and different adiposity levels or distributions. Higher body fat levels are often attributed to excessive dietary intake and/or inadequate physical activity. These environmental influences regulate genes and proteins that alter energy expenditure/storage. Micro ribonucleic acid (miRNAs) can influence these genes and proteins, are sensitive to diet and exercise and may influence the varied metabolic responses observed between individuals. The study aims are to investigate associations between different body fat profiles and metabolic disease risk; dietary and physical activity patterns as predictors of body fat profiles; and whether these risk factors are associated with the expression of microRNAs related to energy expenditure or fat storage in young New Zealand women. Given the rising prevalence of obesity globally, this research will address a unique gap of knowledge in obesity research. Methods/Design: A cross-sectional design to investigate 675 NZ European, Māori, and Pacific women aged 16–45 years. Women are classified into three main body fat profiles (n = 225 per ethnicity; n = 75 per body fat profile): 1) normal BMI, normal body fat percentage (BF%); 2) normal BMI, high BF%; 3) high BMI, high BF%. Regional body composition, biomarkers of metabolic disease risk (i.e. fasting insulin, glucose, HbA1c, lipids), inflammation (i.e. IL-6, TNF-alpha, hs-CRP), associations between lifestyle factors (i.e. dietary intake, physical activity, taste perceptions) and microRNA expression will be investigated. Discussion: This research targets post-menarcheal, premenopausal women, potentially exhibiting lifestyle behaviours resulting in excess body fat affecting metabolic health. These behaviours may be characterised by specific patterns of microRNA expression that will be explored in terms of tailored solutions specific to body fat profile groups and ethnicities. Trial registration: ACTRN12613000714785
dc.description.publication-statusPublished
dc.format.extent? - ? (11)
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000359194100003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef
dc.identifierARTN 128
dc.identifier.citationSPRINGERPLUS, 2015, 4 pp. ? - ? (11)
dc.identifier.doi10.1186/s40064-015-0916-8
dc.identifier.elements-id230868
dc.identifier.harvestedMassey_Dark
dc.identifier.issn2193-1801
dc.languageEnglish
dc.publisherSpringerOpen
dc.relation.isPartOfSPRINGERPLUS
dc.rights© 2015 Kruger et al.; licensee Springer. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
dc.subjectScience & Technology
dc.subjectMultidisciplinary Sciences
dc.subjectScience & Technology - Other Topics
dc.subjectBody fat profile
dc.subjectPredictors
dc.subjectOverweight and obesity
dc.subjectMetabolic disease risk
dc.subjectMicroRNA
dc.subjectDietary practices
dc.subjectPhysical activity
dc.subjectTaste perception
dc.subjectWomen
dc.subjectWEIGHT OBESE SYNDROME
dc.subjectAIR DISPLACEMENT PLETHYSMOGRAPHY
dc.subjectSKELETAL-MUSCLE
dc.subjectMASS INDEX
dc.subjectMETABOLIC SYNDROME
dc.subjectAUSTRALIAN ADULTS
dc.subjectDIETARY PATTERNS
dc.subjectDISEASE
dc.subjectNUTRITION
dc.subjectFOOD
dc.titlePredictors and risks of body fat profiles in young New Zealand European, Māori and Pacific women: study protocol for the women’s EXPLORE study
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Health
pubs.organisational-group/Massey University/College of Health/Research Centre for Hauora and Health
pubs.organisational-group/Massey University/College of Health/School of Sport, Exercise and Nutrition
pubs.organisational-group/Massey University/College of Sciences
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