A nutritional supplement during preconception and pregnancy increases human milk vitamin D but not B-vitamin concentrations.

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dc.citation.issue12
dc.citation.volume42
dc.contributor.authorHan SM
dc.contributor.authorHuang F
dc.contributor.authorDerraik JGB
dc.contributor.authorVickers MH
dc.contributor.authorDevaraj S
dc.contributor.authorRedeuil K
dc.contributor.authorCampos-Giménez E
dc.contributor.authorPang WW
dc.contributor.authorGodfrey KM
dc.contributor.authorChan S-Y
dc.contributor.authorThakkar SK
dc.contributor.authorCutfield WS
dc.contributor.authorNiPPeR Study Group
dc.coverage.spatialEngland
dc.date.accessioned2024-07-14T23:39:40Z
dc.date.available2024-07-14T23:39:40Z
dc.date.issued2023-10-29
dc.description.abstractBACKGROUND & AIMS: Optimal maternal vitamin status during pregnancy and lactation is essential to support maternal and infant health. For instance, vitamin D3 is involved in infant bone development, and B-vitamins are involved in various metabolic processes, including energy production. Through a double-blind randomised controlled trial, we investigated the effects of maternal supplementation from preconception throughout pregnancy until birth on human milk (HM) concentrations of vitamin D3 and B-vitamins. In addition, we aimed to characterise longitudinal changes in milk concentrations of these vitamins. METHODS: Both control and intervention supplements contained calcium, iodine, iron, β-carotene, and folic acid, while the intervention also contained zinc, vitamins B2, B6, B12, and D3, probiotics, and myo-inositol. HM samples were collected across 4 time points from 1 week to 3 months post-delivery from 158 mothers in Singapore, and 7 time points from 1 week to 12 months from 180 mothers in New Zealand. HM vitamin D was quantified using supercritical fluid chromatography and B-vitamins with mass spectrometry. Potential intervention effects on HM vitamins D3, B2, B6, and B9, as well as other B-vitamin (B1 and B3) concentrations were assessed using linear mixed models with a repeated measures design. RESULTS: Over the first 3 months of lactation, HM 25-hydroxyvitamin D3 concentrations were 20% (95% CI 8%, 33%, P = 0.001) higher in the intervention group, with more marked effects in New Zealand. There were no observed intervention effects on HM concentrations of vitamins B1, B2, B3, B6, and B9. In New Zealand mothers, longitudinally, vitamin D3 concentrations gradually increased from early lactation up to 12 months, while vitamins B1 and B2 peaked at 6 weeks, B3 at 3 weeks, and B6 and B9 at 3 months. CONCLUSIONS: Maternal supplementation during preconception and pregnancy increased HM vitamin D, but not B-vitamin concentrations in lactation. Further studies are required to examine the discrete benefits of vitamin D supplementation starting preconception vs during pregnancy, and to further characterise the effects of supplementation on later offspring health outcomes. CLINICAL TRIAL REGISTRATION: Registered at ClinicalTrials.gov on the 16 July 2015 (identifier NCT02509988); Universal Trial Number U1111-1171-8056. This study was academic-led by the EpiGen Global Research Consortium.
dc.description.confidentialfalse
dc.edition.editionDecember 2023
dc.format.pagination2443-2456
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/38411017
dc.identifier.citationHan SM, Huang F, Derraik JGB, Vickers MH, Devaraj S, Redeuil K, Campos-Giménez E, Pang WW, Godfrey KM, Chan S-Y, Thakkar SK, Cutfield WS, NiPPeR Study Group . (2023). A nutritional supplement during preconception and pregnancy increases human milk vitamin D but not B-vitamin concentrations.. Clin Nutr. 42. 12. (pp. 2443-2456).
dc.identifier.doi10.1016/j.clnu.2023.09.009
dc.identifier.eissn1532-1983
dc.identifier.elements-typejournal-article
dc.identifier.issn0261-5614
dc.identifier.piiS0261-5614(23)00295-9
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70174
dc.languageeng
dc.publisherElsevier B.V.
dc.publisher.urihttps://www.sciencedirect.com/science/article/pii/S0261561423002959
dc.relation.isPartOfClin Nutr
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject25(OH)D3
dc.subjectHuman milk
dc.subjectLactation
dc.subjectSupplement
dc.subjectVitamin B
dc.subjectVitamin D
dc.subjectPregnancy
dc.subjectInfant
dc.subjectFemale
dc.subjectHumans
dc.subjectVitamins
dc.subjectVitamin D
dc.subjectMilk, Human
dc.subjectDietary Supplements
dc.subjectCholecalciferol
dc.subjectLactation
dc.subjectVitamin A
dc.subjectDouble-Blind Method
dc.titleA nutritional supplement during preconception and pregnancy increases human milk vitamin D but not B-vitamin concentrations.
dc.typeJournal article
pubs.elements-id484650
pubs.organisational-groupCollege of Health
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