Adaptation of the infant gut microbiome during the complementary feeding transition

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dc.citation.issue7
dc.citation.volume17
dc.contributor.authorMcKeen S
dc.contributor.authorRoy NC
dc.contributor.authorMullaney JA
dc.contributor.authorEriksen H
dc.contributor.authorLovell A
dc.contributor.authorKussman M
dc.contributor.authorYoung W
dc.contributor.authorFraser K
dc.contributor.authorWall CR
dc.contributor.authorMcNabb WC
dc.contributor.editorxia Y
dc.coverage.spatialUnited States
dc.date.accessioned2024-10-18T02:19:04Z
dc.date.available2024-10-18T02:19:04Z
dc.date.issued2022-07-14
dc.description.abstractThe infant gut microbiome progresses in composition and function during the introduction of solid foods throughout the first year of life. The purpose of this study was to characterize changes in healthy infant gut microbiome composition, metagenomic functional capacity, and associated metabolites over the course of the complementary feeding period. Fecal samples were obtained at three 'snapshot' timepoints from infants participating in the 'Nourish to Flourish' pilot study: before the introduction of solid foods at approximately 4 months of age, after introducing solid foods at 9 months of age, and after continued diet diversification at 12 months of age. KEGG and taxonomy assignments were correlated with LC-MS metabolomic profiles to identify patterns of co-abundance. The composition of the microbiome diversified during the first year of life, while the functional capacity present in the gut microbiome remained stable. The introduction of solid foods between 4 and 9 months of age corresponded to a larger magnitude of change in relative abundance of sequences assigned to KEGG pathways and taxonomic assignments, as well as to stronger correlations with metabolites, compared to the magnitude of changes and number of correlations seen during continued diet diversification between 9 and 12 months of age. Changes in aqueous fecal metabolites were more strongly correlated with KEGG pathway assignments, while changes in lipid metabolites associated with taxonomic assignments, particularly between 9 and 12 months of age. This study establishes trends in microbiome composition and functional capacity occurring during the complementary feeding period and identifies potential metabolite targets for future investigations.
dc.description.confidentialfalse
dc.format.paginatione0270213-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/35834499
dc.identifier.citationMcKeen S, Roy NC, Mullaney JA, Eriksen H, Lovell A, Kussman M, Young W, Fraser K, Wall CR, McNabb WC. (2022). Adaptation of the infant gut microbiome during the complementary feeding transition.. PLoS One. 17. 7. (pp. e0270213-).
dc.identifier.doi10.1371/journal.pone.0270213
dc.identifier.eissn1932-6203
dc.identifier.elements-typejournal-article
dc.identifier.issn1932-6203
dc.identifier.numbere0270213
dc.identifier.piiPONE-D-21-23857
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71765
dc.languageeng
dc.publisherPLOS
dc.publisher.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0270213
dc.relation.isPartOfPLoS One
dc.rights(c) 2022 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectFeces
dc.subjectGastrointestinal Microbiome
dc.subjectHumans
dc.subjectInfant
dc.subjectInfant Nutritional Physiological Phenomena
dc.subjectMetagenome
dc.subjectPilot Projects
dc.titleAdaptation of the infant gut microbiome during the complementary feeding transition
dc.typeJournal article
pubs.elements-id454958
pubs.organisational-groupOther
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