Effects of randomized whey-protein loads on energy intake, appetite, gastric emptying, and plasma gut-hormone concentrations in older men and women.

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dc.citation.issue3
dc.citation.volume106
dc.contributor.authorGiezenaar C
dc.contributor.authorTrahair LG
dc.contributor.authorLuscombe-Marsh ND
dc.contributor.authorHausken T
dc.contributor.authorStandfield S
dc.contributor.authorJones KL
dc.contributor.authorLange K
dc.contributor.authorHorowitz M
dc.contributor.authorChapman I
dc.contributor.authorSoenen S
dc.date.available2017-09
dc.date.available2017-06-27
dc.date.issued2017-09
dc.descriptionCAUL read and publish agreement 2022
dc.description.abstractBackground: Protein- and energy-rich supplements are used widely for the management of malnutrition in the elderly. Information about the effects of protein on energy intake and related gastrointestinal mechanisms and whether these differ between men and women is limited.Objective: We determined the effects of whey protein on energy intake, appetite, gastric emptying, and gut hormones in healthy older men and women.Design: Eight older women and 8 older men [mean ± SEM age: 72 ± 1 y; body mass index (in kg/m2): 25 ± 1] were studied on 3 occasions in which they received protein loads of 30 g (120 kcal) or 70 g (280 kcal) or a flavored water control drink (0 kcal). At regular intervals over 180 min, appetite (visual analog scales), gastric emptying (3-dimensional ultrasonography), and blood glucose and plasma gut-hormone concentrations [insulin, glucagon, ghrelin, cholecystokinin, gastric inhibitory polypeptide (GIP), glucagon-like peptide 1 (GLP-1), and peptide tyrosine tyrosine (PYY)] were measured, and ad libitum energy intake was quantified from a buffet meal (180-210 min; energy intake, appetite, and gastric emptying in the men have been published previously).Results: Energy intake at the buffet meal was ∼80% higher in older men than in older women (P < 0.001). Energy intake was not suppressed by protein compared with the control in men or women (P > 0.05). There was no effect of sex on gastric emptying, appetite, gastrointestinal symptoms, glucose, or gut hormones (P > 0.05). There was a protein load-dependent slowing of gastric emptying, an increase in concentrations of insulin, glucagon, cholecystokinin, GIP, GLP-1, and PYY, and an increase in total energy intake (drink plus meal: 12% increase with 30 g and 32% increase with 70 g; P < 0.001). Energy intake at the buffet meal was inversely related to the stomach volume and area under the curve of hormone concentrations (P < 0.05).Conclusion: In older men and women, whey-protein drinks load-dependently slow gastric emptying and alter gut hormone secretion compared with a control but have no suppressive effect on subsequent ad libitum energy intake. This trial was registered at www.anzctr.org.au as ACTRN12612000941864.
dc.description.publication-statusPublished
dc.format.extent865 - 877
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000408890000020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef
dc.identifier.citationAMERICAN JOURNAL OF CLINICAL NUTRITION, 2017, 106 (3), pp. 865 - 877
dc.identifier.doi10.3945/ajcn.117.154377
dc.identifier.eissn1938-3207
dc.identifier.elements-id445474
dc.identifier.harvestedMassey_Dark
dc.identifier.issn0002-9165
dc.relation.isPartOfAMERICAN JOURNAL OF CLINICAL NUTRITION
dc.subjectaging
dc.subjectappetite and energy intake
dc.subjectgastrointestinal function
dc.subjectgastrointestinal mechanisms
dc.subjectsex
dc.subjectwhey protein
dc.subject.anzsrc09 Engineering
dc.subject.anzsrc11 Medical and Health Sciences
dc.titleEffects of randomized whey-protein loads on energy intake, appetite, gastric emptying, and plasma gut-hormone concentrations in older men and women.
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Sciences
pubs.organisational-group/Massey University/College of Sciences/School of Food and Advanced Technology
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