Identification of genetic variants the CCKAR gene and based on body measurement and carcass quality characteristics in Qinchuan beef cattle (Bos taurus)

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dc.citation.volume51
dc.contributor.authorNurgulsim K
dc.contributor.authorRaza SHA
dc.contributor.authorKhan R
dc.contributor.authorShah MA
dc.contributor.authorJahejo AR
dc.contributor.authorBatool U
dc.contributor.authorHongbao W
dc.contributor.authorZhigerbayevich KN
dc.contributor.authorSchreurs N
dc.contributor.authorZan L
dc.date.accessioned2024-04-24T02:51:02Z
dc.date.accessioned2024-07-25T06:43:18Z
dc.date.available2021-02-23
dc.date.available2024-04-24T02:51:02Z
dc.date.available2024-07-25T06:43:18Z
dc.date.issued2021-05
dc.description.abstractBackground: This study aimed to explore genetic polymorphisms of the CCKAR gene and their relationship with the growth and development of Qinchuan cattle which could be used as molecular markers for the improvement of the breeding of Qinchuan cattle. Results: Here, we have identified seven single nucleotide polymorphisms (SNPs) at loci g. 1463 C>G; g. 1532 T>A; g. 1570 G>A; g. 1594 C>A; g. 1640 T>C; g. 1677 G>C; and g. 1735 C>T in the coding region of the bovine CCKAR gene. The frequencies identified on allelic and genotypic characteristics have shown that all seven SNPs diverged from the Hardy-Weinberg-Equilibrium. The SNP2, SNP3, SNP6 and SNP7 had the lowest polymorphism information content values, and remaining SNPs were found to be moderate (0.25 < PIC < 0.50). The genotype CG in SNP1 at loci g.1463 C>G had the greatest association with WH, HW, CD and CCF, while the genotype TA at the very same loci was associated with BFT, ULA and IMF content in Qinchuan cattle. The CCKAR gene expression level in adipose tissue, small intestine, liver and skeleton muscle was found to be higher, whereas, the expression level of mRNA in organs of other digestive system including reticulum, abomasum and omasum was moderate. Some expression of CCKAR mRNA was found in the large intestine, kidney and rumen. Conclusion: In summary, our finding suggested that the CCKAR gene could be used as a potential candidate for the improvement of carcass quality and body measurements of Qinchuan cattle.
dc.description.confidentialfalse
dc.edition.editionMay 2021
dc.format.pagination1-7
dc.identifier.author-urlhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000652394100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef
dc.identifier.citationNurgulsim K, Raza SHA, Khan R, Shah MA, Jahejo AR, Batool U, Hongbao W, Zhigerbayevich KN, Schreurs N, Zan L. (2021). Identification of genetic variants the CCKAR gene and based on body measurement and carcass quality characteristics in Qinchuan beef cattle (Bos taurus). Electronic Journal of Biotechnology. 51. (pp. 1-7).
dc.identifier.doi10.1016/j.ejbt.2021.02.001
dc.identifier.eissn0717-3458
dc.identifier.elements-typejournal-article
dc.identifier.issn0717-3458
dc.identifier.piiS0717345821000051
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70746
dc.languageEnglish
dc.publisherElsevier B.V.
dc.publisher.urihttps://www.sciencedirect.com/science/article/pii/S0717345821000051
dc.relation.isPartOfElectronic Journal of Biotechnology
dc.subjectBody measurement
dc.subjectBos taurus
dc.subjectCarcass
dc.subjectCattle
dc.subjectCCKAR gene
dc.subjectDigestive system
dc.subjectExpression pattern analysis
dc.subjectQinchuan beef cattle
dc.subjectSNP
dc.titleIdentification of genetic variants the CCKAR gene and based on body measurement and carcass quality characteristics in Qinchuan beef cattle (Bos taurus)
dc.typeJournal article
pubs.elements-id442706
pubs.organisational-groupCollege of Health
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