Barbituric acid metabolism in Nocardia corallina : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University

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dc.contributor.authorPearce, Philip David
dc.date.accessioned2017-08-08T02:54:41Z
dc.date.available2017-08-08T02:54:41Z
dc.date.issued1974
dc.description.abstractBarbituric acid utilisation in Nocardia corallina has been investigated. The enzyme barbiturase was induced using barbituric acid as the sole carbon and nitrogen source and a study of the optimum conditions for isolation of the enzyme was undertaken. Although it proved to be somewhat unstable,a partial purification was achieved. Studies of barbituric acid utilisation were undertaken and it was shown that both cell-free extracts and the partially-purified enzyme were capable of the formation of an activated form of malonic acid from barbituric acid. Activation could not be demonstrated using malonic acid as substrate. It is suggested that the barbiturase activity observed in vitro, i.e. malonic acid formation, is an artifact of isolation and that in vivo barbituric acid is utilised via malonyl-CoA.en_US
dc.identifier.urihttp://hdl.handle.net/10179/11630
dc.language.isoenen_US
dc.publisherMassey Universityen_US
dc.rightsThe Authoren_US
dc.subjectNocardia corallinaen_US
dc.subjectMetabolismen_US
dc.titleBarbituric acid metabolism in Nocardia corallina : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey Universityen_US
dc.typeThesisen_US
massey.contributor.authorPearce, Philip David
thesis.degree.disciplineBiochemistryen_US
thesis.degree.grantorMassey Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Science (M. Sc.)en_US
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