Comparison of the effects of 7.2% hypertonic saline and 20% mannitol on whole blood coagulation and platelet function in dogs with suspected intracranial hypertension-a pilot study

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dc.citation.volume13
dc.contributor.authorYozova ID
dc.contributor.authorHoward J
dc.contributor.authorHenke D
dc.contributor.authorDirkmann D
dc.contributor.authorAdamik KN
dc.date.available2017-06-19
dc.date.available2017-06-12
dc.date.issued2017-06-19
dc.description.abstractHyperosmolar therapy with either mannitol or hypertonic saline (HTS) is commonly used in the treatment of intracranial hypertension (ICH). In vitro data indicate that both mannitol and HTS affect coagulation and platelet function in dogs. The aim of this study was to compare the effects of 20% mannitol and 7.2% HTS on whole blood coagulation using rotational thromboelastometry (ROTEM®) and platelet function using a platelet function analyzer (PFA®) in dogs with suspected ICH. Thirty client-owned dogs with suspected ICH needing osmotherapy were randomized to receive either 20% mannitol (5 ml/kg IV over 15 min) or 7.2% HTS (4 ml/kg IV over 5 min). ROTEM® (EXTEM® and FIBTEM® assays) and PFA® analyses (collagen/ADP cartridges) were performed before (T0), as well as 5 (T5), 60 (T60) and 120 (T120) minutes after administration of HTS or mannitol. Data at T5, T60 and T120 were analyzed as a percentage of values at T0 for comparison between groups, and as absolute values for comparison between time points, respectively.No significant difference was found between the groups for the percentage change of any parameter at any time point except for FIBTEM® clotting time. Within each group, no significant difference was found between time points for any parameter except for FIBTEM® clotting time in the HTS group, and EXTEM® and FIBTEM® maximum clot firmness in the mannitol group. Median ROTEM® values lay within institutional reference intervals in both groups at all time points, whereas median PFA® values were above the reference intervals at T5 (both groups) and T60 (HTS group).Using currently recommended doses, mannitol and HTS do not differ in their effects on whole blood coagulation and platelet function in dogs with suspected ICH. Moreover, no relevant impairment of whole blood coagulation was found following treatment with either solution, whereas a short-lived impairment of platelet function was found after both solutions.
dc.description.publication-statusPublished
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000404182600004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef
dc.identifierARTN 185
dc.identifier.citationBMC VETERINARY RESEARCH, 2017, 13
dc.identifier.doi10.1186/s12917-017-1108-2
dc.identifier.elements-id354689
dc.identifier.harvestedMassey_Dark
dc.identifier.issn1746-6148
dc.publisherBioMed Central
dc.relation.isPartOfBMC VETERINARY RESEARCH
dc.relation.urihttps://bmcvetres.biomedcentral.com/articles/10.1186/s12917-017-1108-2
dc.rights© The Author(s). 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.subjectIntracranial hypertension
dc.subjectOsmotherapy
dc.subjectHypertonic saline
dc.subjectMannitol
dc.subjectHemostasis
dc.subjectThromboelastometry
dc.subjectPlatelet function
dc.subject.anzsrc0601 Biochemistry and Cell Biology
dc.subject.anzsrc0605 Microbiology
dc.subject.anzsrc0707 Veterinary Sciences
dc.titleComparison of the effects of 7.2% hypertonic saline and 20% mannitol on whole blood coagulation and platelet function in dogs with suspected intracranial hypertension-a pilot study
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Sciences
pubs.organisational-group/Massey University/College of Sciences/School of Veterinary Science
pubs.organisational-group/Massey University/College of Sciences/School of Veterinary Science/Veterinary Clinic & Teaching Hospital
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