Effects of APOE e4-allele and mental work demands on cognitive decline in old age: Results from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe)

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dc.citation.issue1
dc.citation.volume36
dc.contributor.authorRodriguez FS
dc.contributor.authorRoehr S
dc.contributor.authorPabst A
dc.contributor.authorKleineidam L
dc.contributor.authorFuchs A
dc.contributor.authorWiese B
dc.contributor.authorLühmann D
dc.contributor.authorBrettschneider C
dc.contributor.authorWolfsgruber S
dc.contributor.authorPentzek M
dc.contributor.authorvan den Bussche H
dc.contributor.authorKönig H-H
dc.contributor.authorWeyerer S
dc.contributor.authorWerle J
dc.contributor.authorBickel H
dc.contributor.authorWeeg D
dc.contributor.authorMaier W
dc.contributor.authorScherer M
dc.contributor.authorWagner M
dc.contributor.authorRiedel-Heller SG
dc.coverage.spatialEngland
dc.date.accessioned2024-01-07T19:02:43Z
dc.date.accessioned2024-07-25T06:48:41Z
dc.date.available2020-10
dc.date.available2024-01-07T19:02:43Z
dc.date.available2024-07-25T06:48:41Z
dc.date.issued2021-01
dc.description.abstractObjectives Previous studies have observed protective effects of high mental demands at work on cognitive functioning and dementia risk. However, it is unclear what types of demands drive this effect and whether this effect is subject to a person's genetic risk. We investigated to what extent eight different types of mental demands at work together with the APOE e4 allele, a major risk gene for late-onset Alzheimer's disease, affect cognitive functioning in late life. Methods/Design The population-based German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe, n = 2 154) followed cognitively healthy individuals aged 75 years and older in seven assessment waves. Cognitive functioning was assessed via the mini-mental status examination. Results Mixed-effects modeling (adjusted for education, gender, marital status, stroke, depression, and diabetes) indicated that participants who had an occupational history of working in jobs with high compared to low demands in “Language & Knowledge”, “Pattern detection”, “Information processing”, and “Service” had a slower cognitive decline. APOE e4-allele carriers had an accelerated cognitive decline, but this decline was significantly smaller if they had a medium compared to a low level of demands in contrast to non-carriers. Conclusions Our longitudinal observations suggest that cognitive decline could be slowed by an intellectually enriched lifestyle even in risk gene carriers. Fostering intellectual engagement throughout the life-course could be a key prevention initiative to promote better cognitive health in old age.
dc.format.pagination152-162
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/32819031
dc.identifier.citationRodriguez FS, Roehr S, Pabst A, Kleineidam L, Fuchs A, Wiese B, Lühmann D, Brettschneider C, Wolfsgruber S, Pentzek M, van den Bussche H, König H-H, Weyerer S, Werle J, Bickel H, Weeg D, Maier W, Scherer M, Wagner M, Riedel-Heller SG. (2021). Effects of APOE e4-allele and mental work demands on cognitive decline in old age: Results from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe).. Int J Geriatr Psychiatry. 36. 1. (pp. 152-162).
dc.identifier.doi10.1002/gps.5409
dc.identifier.eissn1099-1166
dc.identifier.elements-typejournal-article
dc.identifier.issn0885-6230
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70933
dc.languageeng
dc.publisherJohn Wiley and Sons Ltd
dc.relation.isPartOfInt J Geriatr Psychiatry
dc.rights(c) 2020 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectcognitive functioning
dc.subjectcognitive reserve
dc.subjectlongitudinal cohort study
dc.subjectmental demands
dc.subjectrisk factors
dc.subjectwork environment
dc.subjectAged
dc.subjectAging
dc.subjectAlleles
dc.subjectApolipoprotein E4
dc.subjectApolipoproteins E
dc.subjectCognition
dc.subjectCognitive Dysfunction
dc.subjectDementia
dc.subjectHumans
dc.subjectLanguage
dc.subjectPrimary Health Care
dc.titleEffects of APOE e4-allele and mental work demands on cognitive decline in old age: Results from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe)
dc.typeJournal article
pubs.elements-id455006
pubs.organisational-groupOther
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