Study protocol - metabolic syndrome, vitamin D and bone status in South Asian women living in Auckland, New Zealand: A randomised, placebo-controlled, double-blind vitamin D intervention

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dc.contributor.authorvon Hurst PR
dc.contributor.authorStonehouse W
dc.contributor.authorMatthys C
dc.contributor.authorConlon C
dc.contributor.authorKruger MC
dc.contributor.authorCoad J
dc.date.accessioned2010-10-07T22:59:26Z
dc.date.accessioned2016-03-06T22:26:04Z
dc.date.availableNO_RESTRICTION
dc.date.available2010-10-07T22:59:26Z
dc.date.available2016-03-06T22:26:04Z
dc.date.issued2008
dc.description.abstractBackground The identification of the vitamin D receptor in the endocrine pancreas suggests a role for vitamin D in insulin secretion. There is also some limited evidence that vitamin D influences insulin resistance, and thus the early stages of the development of type 2 diabetes. Methods Eighty-four women of South Asian origin, living in Auckland, New Zealand, were randomised to receive either a supplement (4000IU 25(OH)D3 per day) or a placebo for 6 months. At baseline, all participants were vitamin D deficient (serum 25(OH)D3 <50 nmol/L), insulin resistant (HOMA-IR > 1.93) and/or hyperinsulinaemic, hyperglycemic or had clinical signs of dislipidaemia. Changes in HOMA-IR, lipids, parathyroid hormone, calcium and bone markers were monitored at 3 months and 6 months. Discussion This randomised, controlled trial will be the first to investigate the effect of vitamin D supplementation on insulin resistance in non-diabetic subjects. It will subsequently contribute to the growing body of evidence about the role of vitamin D in metabolic syndrome.Registered clinical. Trial registration Registered clinical trial – Registration No. ACTRN12607000642482
dc.identifier.citationvon Hurst, P. R., Stonehouse, W., Matthys, C., Conlon, C., Kruger, M. C., & Coad, J. (2008). Study Protocol-Metabolic syndrome, vitamin D and bone status in South Asian women living in Auckland, New Zealand: A randomised, placebo-controlled, double-blind vitamin D intervention. Bmc Public Health, 8(267). doi: 10.1186/1471-2458-8-267
dc.identifier.harvestedMassey_Dark
dc.identifier.harvestedMassey_Dark
dc.identifier.issn1471-2458
dc.language.isoen
dc.publisherBioMed Central Ltd part of Springer Science+Business Media
dc.relation.isbasedonBioMed Central
dc.relation.isformatofhttp://www.biomedcentral.com/1471-2458/8/267
dc.rights2008 von Hurst et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.subjectVitamin D
dc.subjectMetabolic syndrome
dc.subjectInsulin
dc.subjectDiabetes
dc.subjectSupplement
dc.subjectNew Zealand
dc.subject.otherFields of Research::320000 Medical and Health Sciences::321200 Public Health and Health Services::321205 Nutrition and dietetics
dc.titleStudy protocol - metabolic syndrome, vitamin D and bone status in South Asian women living in Auckland, New Zealand: A randomised, placebo-controlled, double-blind vitamin D intervention
dc.typeJournal article
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