Lifestyle for brain health and cognitive functioning in midlife to early late-life New Zealanders: Utility of the LIBRA index.

Simple item page
dc.citation.issue5
dc.citation.volume39
dc.contributor.authorRöhr S
dc.contributor.authorStephens C
dc.contributor.authorAlpass F
dc.coverage.spatialEngland
dc.date.accessioned2024-07-05T02:47:36Z
dc.date.available2024-07-05T02:47:36Z
dc.date.issued2024-05-01
dc.description.abstractOBJECTIVES: There is enormous potential to improve brain health and reduce the risk of cognitive decline and dementia based on modifiable risk factors. The Lifestyle for Brain Health (LIBRA) index was developed to quantify modifiable dementia risk or room for brain health improvement. The objective of the study was to investigate the utility of the LIBRA index in relation to cognitive functioning in a midlife to early late-life sample of New Zealanders. METHODS: A subsample (n = 1001) of the longitudinal New Zealand Health, Work and Retirement (NZHWR) study completed face-to-face cognitive assessments using the 'Kiwi' Addenbrooke's Cognitive Examination-Revised (ACE-R) in 2010 and again in 2012, in addition to completing biennial NZHWR surveys on socioeconomic, health and wellbeing aspects. The LIBRA index was calculated incorporating information on 8 out of 12 modifiable health and lifestyle factors for dementia. Unadjusted and adjusted regression models and mixed effects models were used to inspect associations of LIBRA with cognitive functioning, cognitive impairment, and cognitive decline. RESULTS: The analytical sample (n = 881 [88.0%], after considering exclusion criteria and missing data) had a mean age of 63.1 (SD = 6.5) years, 53.3% were female, 26.2% were Māori, and 61.7% were highly educated. Higher LIBRA scores (indicating higher modifiable dementia risk) were associated with lower cognitive functioning (B = -0.33, 95% CI = -0.52;-0.15, p < 0.001) and a higher likelihood of cognitive impairment (OR = 1.22, 95% CI = 1.04; 1.42, p = 0.013), but did not predict cognitive decline over 2 years (B = -0.03, 95% CI = -0.22; 0.16, p = 0.766), adjusted for age, age2, gender, education, and ethnicity. CONCLUSIONS: The LIBRA index indicated promising utility for quantifying modifiable dementia risk in midlife and early late-life New Zealanders. For local use, refinement of the LIBRA index should consider cultural differences in health and lifestyle risk factors, and further investigate its utility with a wider range of modifiable factors over a longer observation period.
dc.description.confidentialfalse
dc.edition.editionMay 2024
dc.format.paginatione6091-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/38666629
dc.identifier.citationRöhr S, Stephens C, Alpass F. (2024). Lifestyle for brain health and cognitive functioning in midlife to early late-life New Zealanders: Utility of the LIBRA index.. Int J Geriatr Psychiatry. 39. 5. (pp. e6091-).
dc.identifier.doi10.1002/gps.6091
dc.identifier.eissn1099-1166
dc.identifier.elements-typejournal-article
dc.identifier.issn0885-6230
dc.identifier.numbere6091
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70104
dc.languageeng
dc.publisherJohn Wiley and Sons, Inc.
dc.publisher.urihttps://onlinelibrary.wiley.com/doi/10.1002/gps.6091
dc.relation.isPartOfInt J Geriatr Psychiatry
dc.rights(c) 2024 The Author/s
dc.rightsCC BY-NC 4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectLIBRA
dc.subjectNew Zealand
dc.subjectcognitive functioning
dc.subjectcohort study
dc.subjectdementia
dc.subjectlifestyle
dc.subjectprevention
dc.subjectrisk reduction
dc.subjectHumans
dc.subjectNew Zealand
dc.subjectFemale
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectAged
dc.subjectCognitive Dysfunction
dc.subjectLife Style
dc.subjectDementia
dc.subjectRisk Factors
dc.subjectLongitudinal Studies
dc.subjectCognition
dc.subjectAustralasian People
dc.titleLifestyle for brain health and cognitive functioning in midlife to early late-life New Zealanders: Utility of the LIBRA index.
dc.typeJournal article
pubs.elements-id488538
pubs.organisational-groupOther
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Published version.pdf
Size:
225.21 KB
Format:
Adobe Portable Document Format
Description:
488538 PDF.pdf
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
9.22 KB
Format:
Plain Text
Description:
Download
Collections
Journal Articles