Oxidation of independent and combined ingested galactose and glucose during exercise.

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dc.citation.issue5
dc.citation.volume133
dc.contributor.authorOdell OJ
dc.contributor.authorImpey SG
dc.contributor.authorShad BJ
dc.contributor.authorPodlogar T
dc.contributor.authorSalgueiro RB
dc.contributor.authorRowlands DS
dc.contributor.authorWallis GA
dc.coverage.spatialUnited States
dc.date.accessioned2024-06-18T01:16:52Z
dc.date.available2024-06-18T01:16:52Z
dc.date.issued2022-10-06
dc.description.abstractCoingestion of glucose and galactose has been shown to enhance splanchnic extraction and metabolism of ingested galactose at rest; effects during exercise are unknown. This study examined whether combined ingestion of galactose and glucose during exercise enhances exogenous galactose oxidation. Fourteen endurance-trained male and female participants [age, 27 (5) yr; V̇o2peak, 58.1 (7.0) mL·kg−1·min−1] performed cycle ergometry for 150 min at 50% peak power on four occasions, in a randomized counterbalanced manner. During exercise, they ingested beverages providing carbohydrates at rates of 0.4 g.min−1 galactose (GAL), 0.8 g.min−1 glucose (GLU), and on two occasions 0.8 g.min−1 total galactose-glucose (GAL + GLU; 1:1 ratio). Single-monosaccharide 13C-labeling (*) was used to calculate independent (GAL, GLU, GAL* + GLU, and GAL + GLU*) and combined (GAL* + GLU*, COMBINE) exogenous-monosaccharide oxidation between exercise. Plasma galactose concentrations with GAL + GLU [0.4 mmol.L; 95% confidence limits (CL): 0.1, 0.6] were lower (contrast: 0.5 mmol.L; 95% CL: 0.2, 0.8; P < 0.0001) than when GAL alone (0.9 mmol.L; 95% CL: 0.7, 1.2) was ingested. Exogenous carbohydrate oxidation with GAL alone (0.31 g·min−1; 95% CL: 0.28, 0.35) was marginally reduced (contrast: 0.05 g·min−1; 95% CL: −0.09, 0.00007; P = 0.01) when combined with glucose (GAL* + GLU 0.27 g·min−1; 0.24, 0.30). Total combined exogenous-carbohydrate oxidation (COMBINE: 0.57 g·min−1; 95% CL: 0.49, 0.64) was similar (contrast: 0.02 g·min−1; 95% CL: −0.05, 0.09; P = 0.63) when compared with isoenergetic GLU (0.55 g·min−1; 95% CL: 0.52, 0.58). In conclusion, coingestion of glucose and galactose did not enhance exogenous galactose oxidation during exercise. When combined, isoenergetic galactose-glucose ingestion elicited similar exogenous-carbohydrate oxidation to glucose suggesting galactose-glucose blends are a valid alternative for glucose as an exogenous-carbohydrate source during exercise. NEW & NOTEWORTHY Glucose and galactose coingestion blunted the galactosemia seen with galactose-only ingestion during exercise. Glucose and galactose coingestion did not enhance the oxidation of ingested galactose during exercise. Combined galactose-glucose (1:1 ratio) ingestion was oxidized to a similar extent as isoenergetic glucose-only ingestion during exercise. Galactose-glucose blends are a viable exogenous carbohydrate energy source for ingestion during exercise.
dc.description.confidentialfalse
dc.edition.editionNov 2022
dc.format.pagination1166-1174
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/36201325
dc.identifier.citationOdell OJ, Impey SG, Shad BJ, Podlogar T, Salgueiro RB, Rowlands DS, Wallis GA. (2022). Oxidation of independent and combined ingested galactose and glucose during exercise.. J Appl Physiol (1985). 133. 5. (pp. 1166-1174).
dc.identifier.doi10.1152/japplphysiol.00105.2022
dc.identifier.eissn1522-1601
dc.identifier.elements-typejournal-article
dc.identifier.issn8750-7587
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/69879
dc.languageeng
dc.publisherAmerican Physiological Society
dc.publisher.urihttps://journals.physiology.org/doi/full/10.1152/japplphysiol.00105.2022
dc.relation.isPartOfJ Appl Physiol (1985)
dc.rights(c) 2022 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.en
dc.subjectmetabolism
dc.subjectnutrition
dc.subjectphysical activity
dc.subjectsubstrate oxidation
dc.subjectsugars
dc.subjectMale
dc.subjectFemale
dc.subjectHumans
dc.subjectAdult
dc.subjectGlucose
dc.subjectGalactose
dc.subjectOxygen Consumption
dc.subjectBlood Glucose
dc.subjectDietary Carbohydrates
dc.subjectOxidation-Reduction
dc.titleOxidation of independent and combined ingested galactose and glucose during exercise.
dc.typeJournal article
pubs.elements-id457345
pubs.organisational-groupCollege of Health
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