Testing the Effect of Metabolic Rate on DNA Variability at the Intra-Specific Level

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dc.contributor.authorMcGaughran, Angela
dc.contributor.authorHolland, Barbara R.
dc.date.accessioned2010-12-06T23:12:25Z
dc.date.accessioned2016-03-06T22:26:23Z
dc.date.accessioned2016-09-07T13:57:56Z
dc.date.availableNO_RESTRICTIONen_US
dc.date.available2010-12-06T23:12:25Z
dc.date.available2016-03-06T22:26:23Z
dc.date.available2016-09-07T13:57:56Z
dc.date.issued2010-03-15
dc.descriptionFunding: AM was supported by a New Zealand Tertiary Education Commission Top Achievers Doctoral Scholarship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.description.abstractWe tested the metabolic rate hypothesis (whereby rates of mtDNA evolution are postulated to be mediated primarily by mutagenic by-products of respiration) by examining whether mass-specific metabolic rate was correlated with root-to-tip distance on a set of mtDNA trees for the springtail Cryptopygus antarcticus travei from sub-Antarctic Marion Island. Using Bayesian analyses and a novel application of the comparative phylogenetic method, we did not find significant evidence that contemporary metabolic rates directly correlate with mutation rate (i.e., root-to-tip distance) once the underlying phylogeny is taken into account. However, we did find significant evidence that metabolic rate is dependent on the underlying mtDNA tree, or in other words, lineages with related mtDNA also have similar metabolic rates. We anticipate that future analyses which apply this methodology to datasets with longer sequences, more taxa, or greater variability will have more power to detect a significant direct correlation between metabolic rate and mutation rate. We conclude with suggestions for future analyses that would extend the preliminary approach applied here, in particular highlighting ways to tease apart oxidative stress effects from the effects of population size and/or selection coefficients operating on the molecular evolutionary rate.en_US
dc.identifier.citationMcGaughran, A., & Holland, B. R. (2010). Testing the Effect of Metabolic Rate on DNA Variability at the Intra-Specific Level. Plos One, 5(3), e9686. doi: 10.1371/journal.pone.0009686en_US
dc.identifier.harvestedMassey_Dark
dc.identifier.harvestedMassey_Dark
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10179/9730
dc.language.isoenen_US
dc.publisherPLoS Oneen_US
dc.relation.isbasedonPLoS Oneen_US
dc.relation.isformatofhttp://dx.doi.org/10.1371/journal.pone.0009686en_US
dc.rights2010 McGaughran, Holland. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.subjectMetabolic rateen_US
dc.subjectMetabolismen_US
dc.subjectDNAen_US
dc.subjectmtDNAen_US
dc.subjectMolecular evolutionen_US
dc.subjectCryptopygus antarcticus traveien_US
dc.subject.otherFields of Research::270000 Biological Sciences::270200 Genetics::270208 Molecular evolutionen_US
dc.titleTesting the Effect of Metabolic Rate on DNA Variability at the Intra-Specific Levelen_US
dc.typeJournal Articleen_US
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