Supplementation with Astragalus Root Powder Promotes Rumen Microbiota Density and Metabolome Interactions in Lambs

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dc.citation.issue5
dc.citation.volume14
dc.contributor.authorShao P
dc.contributor.authorSha Y
dc.contributor.authorLiu X
dc.contributor.authorHe Y
dc.contributor.authorWang F
dc.contributor.authorHu J
dc.contributor.authorWang J
dc.contributor.authorLi S
dc.contributor.authorChen X
dc.contributor.authorYang W
dc.contributor.authorChen Q
dc.contributor.authorGao M
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-10-23T01:33:47Z
dc.date.available2024-10-23T01:33:47Z
dc.date.issued2024-03-02
dc.description.abstractThe gut microbiota is highly symbiotic with the host, and the microbiota and its metabolites are essential for regulating host health and physiological functions. Astragalus, as a feed additive, can improve animal immunity. However, the effects of Astragalus root powder on the rumen microbiota and their metabolites in lambs are not apparent. In this study, thirty healthy Hu sheep lambs with similar body weights (17.42 ± 2.02 kg) were randomly selected for the feeding experiment. Lambs were fed diets supplemented with 0.3% Astragalus root powder, and the rumen microbiota density and metabolome were measured to determine the effects of Astragalus on the health of lambs in the rumen. The results showed that the relative abundance of Butyrivibrio fibrisolvens (Bf), Ruminococcus flavefaciens (Rf), Succiniclasticum (Su), and Prevotella (Pr) in the rumen was increased in the Astragalus group (p < 0.01), and metabolic profiling showed that the metabolites, such as L-lyrosine and L-leucine, were upregulated in the Astragalus group (p < 0.01). KEGG functional annotation revealed that upregulated metabolites were mainly enriched in the pathways of amino acid metabolism, lipid metabolism, fatty acid biosynthesis, and bile secretion in the Astragalus group, and downregulated metabolites were enriched in the pathways of methane metabolism and other pathways. Correlation analysis revealed that butyric acid was positively correlated with Roseburia and Blautia (p < 0.05) and negatively correlated with Desulfovibrio (p < 0.05). Thus, by analyzing the interactions of Astragalus root powder with the density of rumen microorganisms and their metabolites in lambs, it was shown that Astragalus root powder could improve the structure of rumen microbiota and their metabolites and then participate in the regulation of amino acid metabolism, lipid metabolism, immune metabolism, and other pathways to improve the efficiency of energy absorption of the lambs.
dc.description.confidentialfalse
dc.edition.edition2024
dc.format.pagination788-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/38473173
dc.identifier.citationShao P, Sha Y, Liu X, He Y, Wang F, Hu J, Wang J, Li S, Chen X, Yang W, Chen Q, Gao M. (2024). Supplementation with Astragalus Root Powder Promotes Rumen Microbiota Density and Metabolome Interactions in Lambs.. Animals (Basel). 14. 5. (pp. 788-).
dc.identifier.doi10.3390/ani14050788
dc.identifier.eissn2076-2615
dc.identifier.elements-typejournal-article
dc.identifier.issn2076-2615
dc.identifier.number788
dc.identifier.piiani14050788
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71823
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2076-2615/14/5/788
dc.relation.isPartOfAnimals (Basel)
dc.rights(c) 2024 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAstragalus root powder
dc.subjectlambs
dc.subjectmetabolome
dc.subjectrumen microbiota
dc.titleSupplementation with Astragalus Root Powder Promotes Rumen Microbiota Density and Metabolome Interactions in Lambs
dc.typeJournal article
pubs.elements-id487699
pubs.organisational-groupOther
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