Post-Exertional Malaise May Be Related to Central Blood Pressure, Sympathetic Activity and Mental Fatigue in Chronic Fatigue Syndrome Patients

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dc.citation.issue11
dc.citation.volume10
dc.contributor.authorKujawski S
dc.contributor.authorSłomko J
dc.contributor.authorHodges L
dc.contributor.authorPheby DFH
dc.contributor.authorMurovska M
dc.contributor.authorNewton JL
dc.contributor.authorZalewski P
dc.coverage.spatialSwitzerland
dc.date.accessioned2023-08-24T02:47:42Z
dc.date.accessioned2023-09-04T01:41:34Z
dc.date.available2021-05-26
dc.date.available2023-08-24T02:47:42Z
dc.date.available2023-09-04T01:41:34Z
dc.date.issued2021-06
dc.date.updated2023-08-20T22:47:50Z
dc.descriptionCopyright: © 2021 by the authorsen_US
dc.description.abstractPost-exertional malaise (PEM) is regarded as the hallmark symptom in chronic fatigue syndrome (CFS). The aim of the current study is to explore differences in CFS patients with and without PEM in indicators of aortic stiffness, autonomic nervous system function, and severity of fatigue. One-hundred and one patients met the Fukuda criteria. A Chronic Fatigue Questionnaire (CFQ) and Fatigue Impact Scale (FIS) were used to assess the level of mental and physical fatigue. Aortic systolic blood pressure (sBPaortic) and the autonomic nervous system were measured with the arteriograph and Task Force Monitor, respectively. Eighty-two patients suffered prolonged PEM according to the Fukuda criteria, while 19 did not. Patients with PEM had higher FIS scores (p = 0.02), lower central systolic blood pressure (p = 0.02) and higher mental fatigue (p = 0.03). For a one-point increase in the mental fatigue component of the CFQ scale, the risk of PEM increases by 34%. For an sBPaortic increase of 1 mmHg, the risk of PEM decreases by 5%. For a one unit increase in sympathovagal balance, the risk of PEM increases by 330%. Higher mental fatigue and sympathetic activity in rest are related to an increased risk of PEM, while higher central systolic blood pressure is related to a reduced risk of PEM. However, none of the between group differences were significant after FDR correction, and therefore conclusions should be treated with caution and replicated in further studies.
dc.format.extent2327-
dc.identifierARTN 2327
dc.identifierjcm10112327
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/34073494
dc.identifier.citationKujawski S, Słomko J, Hodges L, Pheby DFH, Murovska M, Newton JL, Zalewski P. (2021). Post-Exertional Malaise May Be Related to Central Blood Pressure, Sympathetic Activity and Mental Fatigue in Chronic Fatigue Syndrome Patients.. J Clin Med. 10. 11. (pp. 2327-).
dc.identifier.doi10.3390/jcm10112327
dc.identifier.eissn2077-0383
dc.identifier.elements-typejournal-article
dc.identifier.harvestedMassey_Dark
dc.identifier.issn2077-0383
dc.identifier.urihttp://hdl.handle.net/10179/19986
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.relation.isPartOfJ Clin Med
dc.rightsCC BYen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectPEM
dc.subjectbrain fog
dc.subjectmyalgic encephalomyelitis
dc.subjectvascular stiffness
dc.titlePost-Exertional Malaise May Be Related to Central Blood Pressure, Sympathetic Activity and Mental Fatigue in Chronic Fatigue Syndrome Patients
dc.typeJournal article
pubs.elements-id446120
pubs.organisational-groupOther
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