A higher-protein nut-based snack product suppresses glycaemia and decreases glycaemic response to co-ingested carbohydrate in an overweight prediabetic Asian Chinese cohort: the Tū Ora postprandial RCT

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dc.citation.volume10
dc.contributor.authorLu LW
dc.contributor.authorSilvestre MP
dc.contributor.authorSequeira IR
dc.contributor.authorPlank LD
dc.contributor.authorFoster M
dc.contributor.authorMiddleditch N
dc.contributor.authorAcevedo-Fani A
dc.contributor.authorHollingsworth KG
dc.contributor.authorPoppitt SD
dc.coverage.spatialEngland
dc.date.accessioned2024-05-20T03:07:39Z
dc.date.available2024-05-20T03:07:39Z
dc.date.issued2021-04-23
dc.description.abstractNut-based products may aid low-glycaemic dietary strategies that are important for diabetes prevention in populations at increased risk of dysglycaemia, such as Asian Chinese. This randomised cross-over trial assessed the postprandial glycaemic response (0-120 min) of a higher-protein nut-based (HP-NB) snack formulation, in bar format (1009 kJ, Nutrient Profiling Score, NPS, -2), when compared with an iso-energetic higher-carbohydrate (CHO) cereal-based bar (HC-CB, 985 kJ, NPS +3). It also assessed the ability to suppress glucose response to a typical CHO-rich food (white bread, WB), when co-ingested. Ten overweight prediabetic Chinese adults (mean, sd: age 47⋅9, 15⋅7 years; BMI 25⋅5, 1⋅6 kg/m2), with total body fat plus ectopic pancreas and liver fat quantified using dual-energy X-ray absorptiometry and magnetic resonance imaging and spectroscopy, received the five meal treatments in random order: HP-NB, HC-CB, HP-NB + WB (50 g available CHO), HC-CB + WB and WB only. Compared with HC-CB, HP-NB induced a significantly lower 30-120 min glucose response (P < 0⋅05), with an approximately 10-fold lower incremental area under the glucose curve (iAUC0-120; P < 0⋅001). HP-NB also attenuated glucose response by approximately 25 % when co-ingested with WB (P < 0⋅05). Half of the cohort had elevated pancreas and/or liver fat, with 13-21 % greater suppression of iAUC0-120 glucose in the low v. high organ fat subgroups across all five treatments. A nut-based snack product may be a healthier alternative to an energy equivalent cereal-based product with evidence of both a lower postprandial glycaemic response and modulation of CHO-induced hyperglycaemia even in high-risk, overweight, pre-diabetic adults.
dc.description.confidentialfalse
dc.format.paginatione30-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/34094511
dc.identifier.citationLu LW, Silvestre MP, Sequeira IR, Plank LD, Foster M, Middleditch N, Acevedo-Fani A, Hollingsworth KG, Poppitt SD. (2021). A higher-protein nut-based snack product suppresses glycaemia and decreases glycaemic response to co-ingested carbohydrate in an overweight prediabetic Asian Chinese cohort: the Tū Ora postprandial RCT.. J Nutr Sci. 10. (pp. e30-).
dc.identifier.doi10.1017/jns.2021.20
dc.identifier.eissn2048-6790
dc.identifier.elements-typejournal-article
dc.identifier.issn2048-6790
dc.identifier.numbere30
dc.identifier.piiS2048679021000203
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/69612
dc.languageeng
dc.publisherCambridge University Press on behalf of The Nutrition Society
dc.publisher.urihttps://www.cambridge.org/core/journals/journal-of-nutritional-science/article/higherprotein-nutbased-snack-product-suppresses-glycaemia-and-decreases-glycaemic-response-to-coingested-carbohydrate-in-an-overweight-prediabetic-asian-chinese-cohort-the-tu-ora-postprandial-rct/097C62F670DB4A3F59840E53C2CE3677#article
dc.relation.isPartOfJ Nutr Sci
dc.rights(c) 2021 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAUC, area under the curve
dc.subjectBF, body fat
dc.subjectBMI, body mass index
dc.subjectCHO, carbohydrate
dc.subjectDXA, dual-energy X-ray absorptiometry
dc.subjectDried fruits
dc.subjectGI, glycaemic index
dc.subjectMRI
dc.subjectMRI, magnetic resonance imaging
dc.subjectMRS, magnetic resonance spectroscopy
dc.subjectNuts
dc.subjectPostprandial glycaemia
dc.subjectPrediabetes
dc.subjectSAT, subcutaneous adipose tissue
dc.subjectT2D, type 2 diabetes
dc.subjectVAS, visual analogue scales
dc.subjectVAT, visceral adipose tissue
dc.subjectWB, white bread
dc.subjectiAUC, incremental area under the curve
dc.subjectAdult
dc.subjectBlood Glucose
dc.subjectChina
dc.subjectDietary Carbohydrates
dc.subjectDietary Proteins
dc.subjectEdible Grain
dc.subjectGlucose
dc.subjectGlycemic Index
dc.subjectHumans
dc.subjectInsulin
dc.subjectNuts
dc.subjectOverweight
dc.subjectPrediabetic State
dc.subjectSnacks
dc.titleA higher-protein nut-based snack product suppresses glycaemia and decreases glycaemic response to co-ingested carbohydrate in an overweight prediabetic Asian Chinese cohort: the Tū Ora postprandial RCT
dc.typeJournal article
pubs.elements-id445414
pubs.organisational-groupOther
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