IKVAV-linked cell membrane-spanning peptide treatment induces neuronal reactivation following spinal cord injury

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dc.citation.issue4
dc.citation.volume1
dc.contributor.authorKazemi S
dc.contributor.authorBaltzer WI
dc.contributor.authorSchilke K
dc.contributor.authorMansouri H
dc.contributor.authorMata JE
dc.date.available2015-10-27
dc.date.issued2015-10-27
dc.description.abstractSpinal cord regeneration following treatment with a novel membrane-spanning peptide (MSP) expressing the isoleucine-lysine-valine-alanine-valine (IKVAV) epitope was assessed in Balb-c mice. After hemilaminectomy and compression injury, mice were treated with IKVAV, IKVAV-MSP, peptide or vehicle control. Functional improvement was assessed using modified Basso, Beattie, and Bresnahan Scale (mBBB) and spinal cord segments were studied histologically 28 days after injury. IKVAV-MSP group scores increased significantly compared with control groups after 4 weeks of observation (p < 0.05). The number of protoplasmic astrocytes, neurons and muscle bundle size in the IKVAV-MSP mice were significantly increased (p < 0.001; p < 0.05 and p < 0.007; respectively). This study demonstrates that it is possible to promote functional recovery after SCI using bioactive IKVAV presenting cell membrane-spanning peptides. Lay abstract: A new potential treatment for spinal cord injury was tested in mice. Mice were treated with our membrane-spanning peptide with the IKVAV motif (IKVAV-MSP) or various control treatments. Functional improvement was assessed daily and spinal cord segments were evaluated after 4 weeks. IKVAV-MSP treatment significantly restored function compared with control groups, numbers of health nerve cells within the spinal cord were increased and muscles appeared healthier. This study demonstrates that it is possible to promote functional recovery after SCI using bioactive IKVAV presenting cell membrane-spanning peptides.
dc.description.confidentialfalse
dc.format.extent1 - 10
dc.identifierhttps://doi.org/10.4155/fso.15.81
dc.identifier.citationFuture Science OA, 2015, 1 (4), pp. 1 - 10
dc.identifier.doi10.4155/fso.15.81
dc.identifier.eissn2056-5623
dc.identifier.elements-id386803
dc.identifier.harvestedMassey_Dark
dc.publisher.urihttps://doi.org/10.4155/fso.15.81
dc.relation.isPartOfFuture Science OA
dc.rights© John Enrique Mata. This work is licensed under the Creative Commons Attribution 4.0 License.
dc.subjectspinal cord injury
dc.subjectregeneration
dc.subjectIKVAV
dc.subjectregeneration
dc.subjectmembrane-spanning peptide
dc.titleIKVAV-linked cell membrane-spanning peptide treatment induces neuronal reactivation following spinal cord injury
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Sciences
pubs.organisational-group/Massey University/College of Sciences/School of Veterinary Science
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