The Role of Lifestyle and Dietary Factors in the Development of Premature Ovarian Insufficiency

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dc.citation.issue8
dc.citation.volume12
dc.contributor.authorShelling AN
dc.contributor.authorAhmed Nasef N
dc.contributor.editorDimitriadis, F
dc.contributor.editorSofikitis N
dc.contributor.editorSulyok E
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-10-10T19:28:24Z
dc.date.available2024-10-10T19:28:24Z
dc.date.issued2023-08-11
dc.description.abstractPremature ovarian insufficiency (POI) is a condition that arises from dysfunction or early depletion of the ovarian follicle pool accompanied by an earlier-than-normal loss of fertility in young women. Oxidative stress has been suggested as an important factor in the decline of fertility in women and POI. In this review, we discuss the mechanisms of oxidative stress implicated in ovarian ageing and dysfunction in relation to POI, in particular mitochondrial dysfunction, apoptosis and inflammation. Genetic defects, autoimmunity and chemotherapy, are some of the reviewed hallmarks of POI that can lead to increased oxidative stress. Additionally, we highlight lifestyle factors, including diet, low energy availability and BMI, that can increase the risk of POI. The final section of this review discusses dietary factors associated with POI, including consumption of oily fish, mitochondria nutrient therapy, melatonin, dairy and vitamins that can be targeted as potential interventions, especially for at-risk women and in combination with personalised nutrition. Understanding the impact of lifestyle and its implications for POI and oxidative stress holds great promise in reducing the burden of this condition.
dc.description.confidentialfalse
dc.edition.editionAugust 2023
dc.format.pagination1601-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37627595
dc.identifier.citationShelling AN, Ahmed Nasef N. (2023). The Role of Lifestyle and Dietary Factors in the Development of Premature Ovarian Insufficiency.. Antioxidants (Basel). 12. 8. (pp. 1601-).
dc.identifier.doi10.3390/antiox12081601
dc.identifier.eissn2076-3921
dc.identifier.elements-typejournal-article
dc.identifier.issn2076-3921
dc.identifier.number1601
dc.identifier.piiantiox12081601
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71679
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2076-3921/12/8/1601
dc.relation.isPartOfAntioxidants (Basel)
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectdiet
dc.subjectearly menopause
dc.subjectinfertility
dc.subjectlifestyle
dc.subjectovarian ageing
dc.subjectoxidative stress
dc.subjectpremature ovarian insufficiency
dc.titleThe Role of Lifestyle and Dietary Factors in the Development of Premature Ovarian Insufficiency
dc.typeJournal article
pubs.elements-id480250
pubs.organisational-groupOther
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