Investigation of the gastric digestion behavior of commercial infant formulae using an in vitro dynamic infant digestion model.

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dc.citation.volume11
dc.contributor.authorDescallar FB
dc.contributor.authorRoy D
dc.contributor.authorWang X
dc.contributor.authorZhu P
dc.contributor.authorYe A
dc.contributor.authorLiang Y
dc.contributor.authorPundir S
dc.contributor.authorSingh H
dc.contributor.authorAcevedo-Fani A
dc.contributor.editorLambers T
dc.coverage.spatialSwitzerland
dc.date.accessioned2025-01-06T20:17:24Z
dc.date.available2025-01-06T20:17:24Z
dc.date.issued2024-12-05
dc.description.abstractThe gastric digestion behavior of different commercial Stage 1 infant formulae (for 0-6 months) with different formulation backgrounds was investigated using an in vitro dynamic infant human gastric simulator (iHGS). The microstructural arrangements of the protein and lipid, colloidal stability and protein hydrolysis during digestion were elucidated. During gastric digestion, casein-dominant formulations showed a higher extent of aggregation due to their high proportion of casein micelles that underwent coagulation upon acidification and via the action of pepsin. The extensive protein coagulation/curd formation in casein-dominant infant formulae slowed the rate of protein hydrolysis and resulted in the retention of caseins in the iHGS for longer times. Confocal micrographs showed that oil droplets were entrapped in the curd particles of casein-dominant infant formulae, which consequently slowed the gastric emptying of lipids. Conversely, whey-dominant formulations showed a lower degree of protein aggregation that resulted in faster protein hydrolysis and rapid protein and lipid emptying from the iHGS. It was also revealed that whey-dominant infant formulae in the presence of biopolymers increased the viscosity of gastric chyme and induced the flocculation of oil droplets. This altered the rate of protein hydrolysis and emptying of lipids. Correlation analyses depicted the overall kinetics of gastric emptying of macronutrients during digestion and comprised two stages: (i) driven by the continuous stomach emptying and (ii) influenced by aggregation and coalescence indices. The present study highlights the similarities and differences in the digestion behaviors of commercial infant formulae based on important ingredients such as types of proteins and biopolymers, regardless of the formulation or processing histories.
dc.description.confidentialfalse
dc.format.pagination1507093-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/39703338
dc.identifier.citationDescallar FB, Roy D, Wang X, Zhu P, Ye A, Liang Y, Pundir S, Singh H, Acevedo-Fani A. (2024). Investigation of the gastric digestion behavior of commercial infant formulae using an in vitro dynamic infant digestion model.. Front Nutr. 11. (pp. 1507093-).
dc.identifier.doi10.3389/fnut.2024.1507093
dc.identifier.eissn2296-861X
dc.identifier.elements-typejournal-article
dc.identifier.issn2296-861X
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/72322
dc.languageeng
dc.publisherFrontiers Media S.A.
dc.publisher.urihttp://frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1507093/full
dc.relation.isPartOfFront Nutr
dc.rights(c) 2024 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectbiopolymers
dc.subjectgastric emptying
dc.subjectin vitro dynamic digestion
dc.subjectinfant formula
dc.subjectmilk proteins
dc.titleInvestigation of the gastric digestion behavior of commercial infant formulae using an in vitro dynamic infant digestion model.
dc.typeJournal article
pubs.elements-id492809
pubs.organisational-groupOther
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