The association between retinal vein ophthalmodynamometric force change and optic disc excavation

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dc.contributor.authorMorgan WH
dc.contributor.authorHazelton ML
dc.contributor.authorBalaratnasingamm C
dc.contributor.authorChan H
dc.contributor.authorHouse PH
dc.contributor.authorBarry CJ
dc.contributor.authorCringle SJ
dc.contributor.authorYu D
dc.date.accessioned2010-11-25T03:37:25Z
dc.date.accessioned2016-03-06T22:26:15Z
dc.date.availableNO_RESTRICTION
dc.date.available2010-11-25T03:37:25Z
dc.date.available2016-03-06T22:26:15Z
dc.date.issued2009
dc.description.abstractAim: Retinal vein ophthalmodynamometric force (ODF) is predictive of future optic disc excavation in glaucoma, but it is not known if variation in ODF affects prognosis. We aimed to assess whether a change in ODF provides additional prognostic information. Methods: 135 eyes of 75 patients with glaucoma or being glaucoma suspects had intraocular pressure (IOP), visual fields, stereo optic disc photography and ODF measured on an initial visit and a subsequent visit at mean 82 (SD 7.3) months later. Corneal thickness and blood pressure were recorded on the latter visit. When venous pulsation was spontaneous, the ODF was recorded as 0 g. Change in ODF was calculated. Flicker stereochronoscopy was used to determine the occurrence of optic disc excavation, which was modelled against the measured variables using multiple mixed effects logistic regression. Results: Change in ODF (p = 0.046) was associated with increased excavation. Average IOP (p = 0.66) and other variables were not associated. Odds ratio for increased optic disc excavation of 1.045 per gram ODF change (95% CI 1.001 to 1.090) was calculated. Conclusion: Change in retinal vein ODF may provide additional information to assist with glaucoma prognostication and implies a significant relationship between venous change and glaucoma patho-physiology.
dc.identifier.citationMorgan, W. H., Hazelton, M. L., Balaratnasingamm, C., Chan, H., House, P. H., Barry, C. J., et al. (2009). The association between retinal vein ophthalmodynamometric force change and optic disc excavation. British Journal of Ophthalmology, 93(5), 594-596. doi: 10.1136/bjo.2008.149963
dc.identifier.harvestedMassey_Dark
dc.identifier.harvestedMassey_Dark
dc.identifier.issn0007-1161
dc.language.isoen
dc.publisherBritish Medical Journal
dc.relation.isbasedonBMJ Publishing Group
dc.relation.isformatofhttp://bjo.bmj.com/content/93/5/594
dc.relation.isformatofhttp://dx.doi.org/10.1136/bjo.2008.149963
dc.subjectOptic disc
dc.subjectRetinal vein
dc.subjectOphthalmodynamometric force
dc.subjectODF
dc.subjectGlaucoma
dc.subject.otherFields of Research::320000 Medical and Health Sciences::321000 Clinical Sciences::321016 Opthalmology and vision science
dc.titleThe association between retinal vein ophthalmodynamometric force change and optic disc excavation
dc.typeJournal article
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