Amino acid requirements of the infant: the amino acid composition of human breast milk

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dc.citation.volume11
dc.contributor.authorMoughan PJ
dc.contributor.authorDeglaire A
dc.contributor.authorYan Y
dc.contributor.authorWescombe P
dc.contributor.authorLim WXJ
dc.contributor.authorStroebinger N
dc.contributor.authorDuan S
dc.contributor.authorSzeto IM-Y
dc.contributor.authorHodgkinson S
dc.contributor.editorFreitas HR
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-10-17T02:14:54Z
dc.date.available2024-10-17T02:14:54Z
dc.date.issued2024-09-17
dc.description.abstractThe recommended amino acid requirements of the infant are based on the amino acid composition of mature human breast milk. The amino acid composition of breast milk is usually determined following either acid or alkaline (for tryptophan) hydrolysis. For accuracy, however, the known effect of hydrolysis time on amino acid composition should be accounted for. Also, ideally the amino acid composition of breast milk should be given in units of digested (assumed to be absorbed) amino acids. A review of the literature is presented which gives mean total amino acid concentrations in mature human milk (n = 26 studies), mean hydrolysis correction factors (n = 3 studies) and mean true ileal amino acid digestibility coefficients (n = 3 studies, suckling piglet). There were differences between the estimates of amino acid concentration corrected for hydrolysis time and digestibility, and current FAO (2013) recommendations that were not corrected for these factors. The values based on the published literature up until 2023 (mg/g true protein) corrected for hydrolysis time and digestibility gave higher values (more than 16% higher) for leucine, lysine and threonine, and considerably higher values (greater than 30%) for histidine and tryptophan. Current recommendations may need revision.
dc.description.confidentialfalse
dc.format.pagination1446565-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/39355558
dc.identifier.citationMoughan PJ, Deglaire A, Yan Y, Wescombe P, Lim WXJ, Stroebinger N, Duan S, Szeto IM-Y, Hodgkinson S. (2024). Amino acid requirements of the infant: the amino acid composition of human breast milk.. Front Nutr. 11. (pp. 1446565-).
dc.identifier.doi10.3389/fnut.2024.1446565
dc.identifier.eissn2296-861X
dc.identifier.elements-typejournal-article
dc.identifier.issn2296-861X
dc.identifier.number1446565
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71749
dc.languageeng
dc.publisherFrontiers Media S.A.
dc.publisher.urihttps://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1446565/full
dc.relation.isPartOfFront Nutr
dc.rights(c) 2024 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectbreast milk
dc.subjecthuman milk
dc.subjecthuman milk protein
dc.subjectindispensable amino acid
dc.subjectinfant nutrition
dc.subjectlactation
dc.subjectprotein hydrolysis
dc.subjecttrue ileal amino acid digestibility
dc.titleAmino acid requirements of the infant: the amino acid composition of human breast milk
dc.typeJournal article
pubs.elements-id491761
pubs.organisational-groupOther
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