The kinetics of amino acid disappearance in the small intestine is related to the extent of amino acids absorbed in growing pigs

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dc.citation.issue5
dc.citation.volume131
dc.contributor.authorMontoya CA
dc.contributor.authorvan Bemmel M
dc.contributor.authorKreutz K
dc.contributor.authorHodgkinson SM
dc.contributor.authorStroebinger N
dc.contributor.authorMoughan PJ
dc.coverage.spatialEngland
dc.date.accessioned2024-10-21T23:43:17Z
dc.date.available2024-10-21T23:43:17Z
dc.date.issued2024-03-14
dc.description.abstractThis study evaluated the importance of a correction for amino acids (AA) released into the hindgut on a measure of AA absorption kinetics and tested whether AA absorption kinetics are related to the extent of AA absorption using the growing pig as a model for humans. Thirty-six nine-week-old pigs (22·3 kg) received a diet containing whey protein as the sole protein source for 8 d. Pigs received their last meal containing the indigestible marker titanium dioxide before being euthanised at 1, 2, 3, 4, 6 and 12 h post-feeding. The entire content of each gastrointestinal tract (GIT) region was collected to determine AA released into the hindgut, and the kinetics and extent of AA absorption (uncorrected and corrected for AA entering the hindgut). Amounts of AA released into the hindgut increased over time (e.g. 33 and 180 mg of Glu for 4 and 6 h post-feeding). The corrected apparent amount of each AA absorbed from the GIT lumen after 4 h post-feeding was generally lower (P ≤ 0·05) than the uncorrected counterpart. Differences in both the kinetics and extent of AA absorption were observed across AA. For example, the time to reach half of the apparent AA absorption (T50) was 1·5 and 3·4 h for Met and Arg, respectively, whereas their extent of apparent absorption was 93 and 73 %. Negative correlations between parameters related to kinetics and the extent of apparent absorption were observed (e.g. for T50 r = -0·81; P < 0·001). The kinetics of AA absorption is related to the extent of AA absorption.
dc.description.confidentialfalse
dc.format.pagination762-772
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37881009
dc.identifier.citationMontoya CA, van Bemmel M, Kreutz K, Hodgkinson SM, Stroebinger N, Moughan PJ. (2024). The kinetics of amino acid disappearance in the small intestine is related to the extent of amino acids absorbed in growing pigs.. Br J Nutr. 131. 5. (pp. 762-772).
dc.identifier.doi10.1017/S0007114523002441
dc.identifier.eissn1475-2662
dc.identifier.elements-typejournal-article
dc.identifier.issn0007-1145
dc.identifier.piiS0007114523002441
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71796
dc.languageeng
dc.publisherCambridge University Press on behalf of The Nutrition Society
dc.publisher.urihttps://www.cambridge.org/core/journals/british-journal-of-nutrition/article/kinetics-of-amino-acid-disappearance-in-the-small-intestine-is-related-to-the-extent-of-amino-acids-absorbed-in-growing-pigs/2B6CFB8925053C45653D1CC93B0F07F8#article
dc.relation.isPartOfBr J Nutr
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAmino acids
dc.subjectKinetics of absorption
dc.subjectPigs
dc.subjectTransit time
dc.subjectHumans
dc.subjectSwine
dc.subjectAnimals
dc.subjectAmino Acids
dc.subjectDigestion
dc.subjectIntestine, Small
dc.subjectGastrointestinal Tract
dc.subjectDiet
dc.subjectAnimal Feed
dc.subjectIleum
dc.subjectAnimal Nutritional Physiological Phenomena
dc.titleThe kinetics of amino acid disappearance in the small intestine is related to the extent of amino acids absorbed in growing pigs
dc.typeJournal article
pubs.elements-id484278
pubs.organisational-groupOther
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