Detection of a Novel Papillomavirus Type within a Feline Cutaneous Basal Cell Carcinoma

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dc.citation.issue12
dc.citation.volume9
dc.contributor.authorMunday JS
dc.contributor.authorHunt H
dc.contributor.authorOrbell G
dc.contributor.authorPfeffer H
dc.contributor.editorBennett P
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-02-01T20:12:43Z
dc.date.accessioned2024-07-25T06:46:12Z
dc.date.available2022-12
dc.date.available2024-02-01T20:12:43Z
dc.date.available2024-07-25T06:46:12Z
dc.date.issued2022-12-01
dc.description.abstractA 4 cm diameter exophytic mass was excised from the left flank of a 10-year-old domestic short-haired cat. Histology of the superficial aspects of the mass revealed epidermal cells arranged in nests and trabeculae while the deeper parts of the mass consisted of small round cells arranged in sheets or bundles of elongate spindle-shaped cells. A diagnosis of basal cell carcinoma (BCC) was made. Approximately 40% of the cells throughout the neoplasm contained prominent papillomaviral (PV)-induced cell changes. The BCC recurred three months after excision and grew rapidly. At this time a smaller mass was observed on the thorax. Due to the rapid recurrence of the BCC, the cat was euthanatized. As in the initial mass, histology of the recurrent mass revealed pleomorphic cells that often contained PV-induced cell changes. In contrast, the thoracic mass appeared as a more typical BCC and contained no histological evidence of PV infection. A novel PV DNA sequence was amplified from the flank BCC. While the sequence was most (75.1%) similar to Felis catus papillomavirus (FcaPV) 6, the level of similarity between the sequences is consistent with a novel PV type. No PV DNA was amplifiable from the thoracic mass. The case is unique due to the histological features of the BCC and the presence of a putative novel PV type. Observations from the present case add to the number of PV types associated with disease in cats as well as increasing the spectrum of PV-induced lesions in this species.
dc.description.confidentialfalse
dc.edition.editionDecember 2022
dc.format.pagination671-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/36548831
dc.identifier.citationMunday JS, Hunt H, Orbell G, Pfeffer H. (2022). Detection of a Novel Papillomavirus Type within a Feline Cutaneous Basal Cell Carcinoma.. Vet Sci. 9. 12. (pp. 671-).
dc.identifier.doi10.3390/vetsci9120671
dc.identifier.eissn2306-7381
dc.identifier.elements-typejournal-article
dc.identifier.issn2306-7381
dc.identifier.number671
dc.identifier.piivetsci9120671
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70833
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2306-7381/9/12/671
dc.relation.isPartOfVet Sci
dc.rights(c) The author/sen
dc.rights.licenseCC BY 4.0en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectbasal cell carcinoma
dc.subjectcancer
dc.subjectcarcinogenesis
dc.subjectcat
dc.subjectneoplasia
dc.subjectpapillomavirus
dc.subjectskin
dc.titleDetection of a Novel Papillomavirus Type within a Feline Cutaneous Basal Cell Carcinoma
dc.typeJournal article
pubs.elements-id458623
pubs.organisational-groupOther
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