Recent Advances in Understanding the Molecular Basis of Infantile Haemangioma Development

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dc.citation.volumeAccepted manuscript
dc.contributor.authorMitra R
dc.contributor.authorFitzsimmons H
dc.contributor.authorHale T
dc.contributor.authorTan ST
dc.contributor.authorGray C
dc.contributor.authorWhite MPJ
dc.coverage.spatialEngland
dc.date.accessioned2024-07-17T22:12:41Z
dc.date.available2024-07-17T22:12:41Z
dc.date.issued2024-06-07
dc.description.abstractInfantile haemangioma (IH), the most common vascular tumour of infancy, is comprised of diverse cell types including endothelial cells, pericytes, fibroblasts and immune cells. IH is characterized by rapid proliferation followed by slow involution over 1 - 10 years. Most lesions regress spontaneously, but up to 10% can be disfiguring with complications that require further medical treatment. Recent research has revealed the biological characteristics of IH, highlighting the involvement of angiogenesis and vasculogenesis during tumour formation. Gene expression profiling has provided vital insights into these underlying biological processes, with some of the key IH-related pathways identified, including VEGF, RAAS, HIF-1α, Notch, PDGF, PI3K/Akt/mTOR, JAK/STAT, FGF, PPARγ, IGF. Further evidence suggests extracellular matrix factors and hormone receptors regulate IH progression. In this review, we explore the molecular mechanisms involved in the proliferating, plateau and involuting phases of IH. This involves identifying differentially expressed genes, targeted proteins, and key signalling pathways. This knowledge will increase the broader understanding of vascular development, tissue remodelling and angiogenesis.
dc.description.confidentialfalse
dc.format.paginationljae241-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/38845569
dc.identifier.citationMitra R, Fitzsimmons H, Hale T, Tan ST, Gray C, White MPJ. (2024). Recent Advances in Understanding the Molecular Basis of Infantile Haemangioma Development.. Br J Dermatol. Accepted manuscript. (pp. ljae241-).
dc.identifier.doi10.1093/bjd/ljae241
dc.identifier.eissn1365-2133
dc.identifier.elements-typejournal-article
dc.identifier.issn0007-0963
dc.identifier.numberljae241
dc.identifier.pii7689274
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70215
dc.languageeng
dc.publisherOxford University Press on behalf of the British Association of Dermatologists
dc.publisher.urihttps://academic.oup.com/bjd/advance-article/doi/10.1093/bjd/ljae241/7689274
dc.relation.isPartOfBr J Dermatol
dc.rights(c) The author/sen
dc.rights.licenseCC BYen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.titleRecent Advances in Understanding the Molecular Basis of Infantile Haemangioma Development
dc.typeJournal article
pubs.elements-id489598
pubs.organisational-groupOther
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