Disentangling the relationship of subjective cognitive decline and depressive symptoms in the development of cognitive decline and dementia

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dc.citation.issue5
dc.citation.volume19
dc.contributor.authorKleineidam L
dc.contributor.authorWagner M
dc.contributor.authorGuski J
dc.contributor.authorWolfsgruber S
dc.contributor.authorMiebach L
dc.contributor.authorBickel H
dc.contributor.authorKönig H-H
dc.contributor.authorWeyerer S
dc.contributor.authorLühmann D
dc.contributor.authorKaduszkiewicz H
dc.contributor.authorLuppa M
dc.contributor.authorRöhr S
dc.contributor.authorPentzek M
dc.contributor.authorWiese B
dc.contributor.authorMaier W
dc.contributor.authorScherer M
dc.contributor.authorKornhuber J
dc.contributor.authorPeters O
dc.contributor.authorFrölich L
dc.contributor.authorWiltfang J
dc.contributor.authorLewczuk P
dc.contributor.authorHüll M
dc.contributor.authorRamirez A
dc.contributor.authorJessen F
dc.contributor.authorRiedel-Heller SG
dc.contributor.authorHeser K
dc.coverage.spatialUnited States
dc.date.accessioned2023-12-15T01:22:03Z
dc.date.accessioned2024-07-25T06:50:26Z
dc.date.available2022-10-11
dc.date.available2023-12-15T01:22:03Z
dc.date.available2024-07-25T06:50:26Z
dc.date.issued2023-05
dc.description.abstractIntroduction Subjective cognitive decline (SCD) and depressive symptoms (DS) frequently co-occur prior to dementia. However, the temporal sequence of their emergence and their combined prognostic value for cognitive decline and dementia is unclear. Methods Temporal relationships of SCD, DS and memory decline were examined by latent difference score modeling in a high-aged, population-based cohort (N = 3217) and validated using Cox-regression of dementia-conversion. In 334 cognitively unimpaired SCD-patients from memory-clinics, we examined the association of DS with cognitive decline and with cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers. Results In the population-based cohort, SCD preceded DS. High DS were associated with increased risk of dementia conversion in individuals with SCD. In SCD-patients from memory-clinics, high DS were associated with greater cognitive decline. CSF Aß42 predicted increasing DS. Discussion SCD typically precedes DS in the evolution to dementia. SCD-patients from memory-clinics with DS may constitute a high-risk group for cognitive decline. Highlights Subjective cognitive decline (SCD) precedes depressive symptoms (DS) as memory declines. Emerging or persistent DS after SCD reports predict dementia. In SCD patients, more amyloid pathology relates to increasing DS. SCD patients with DS are at high risk for symptomatic progression.
dc.format.pagination2056-2068
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/36218120
dc.identifier.citationKleineidam L, Wagner M, Guski J, Wolfsgruber S, Miebach L, Bickel H, König H-H, Weyerer S, Lühmann D, Kaduszkiewicz H, Luppa M, Röhr S, Pentzek M, Wiese B, Maier W, Scherer M, Kornhuber J, Peters O, Frölich L, Wiltfang J, Lewczuk P, Hüll M, Ramirez A, Jessen F, Riedel-Heller SG, Heser K. (2023). Disentangling the relationship of subjective cognitive decline and depressive symptoms in the development of cognitive decline and dementia.. Alzheimers Dement. 19. 5. (pp. 2056-2068).
dc.identifier.doi10.1002/alz.12785
dc.identifier.eissn1552-5279
dc.identifier.elements-typejournal-article
dc.identifier.issn1552-5260
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70985
dc.languageeng
dc.publisherWiley Periodicals LLC on behalf of Alzheimer's Association
dc.relation.isPartOfAlzheimers Dement
dc.rights(c) The author/sen
dc.rights.licenseCC BY-NC-NDen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectAlzheimer's disease
dc.subjectdepression
dc.subjectlatent difference score model
dc.subjectsubjective cognitive decline
dc.subjecttemporal sequence
dc.subjectHumans
dc.subjectAged
dc.subjectDepression
dc.subjectAlzheimer Disease
dc.subjectCognitive Dysfunction
dc.subjectBiomarkers
dc.subjectAmyloid beta-Peptides
dc.titleDisentangling the relationship of subjective cognitive decline and depressive symptoms in the development of cognitive decline and dementia
dc.typeJournal article
pubs.elements-id457388
pubs.organisational-groupOther
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