Genomic Regions Associated with Milk Composition and Fertility Traits in Spring-Calved Dairy Cows in New Zealand

Simple item page
dc.citation.issue4
dc.citation.volume14
dc.contributor.authorJayawardana JMDR
dc.contributor.authorLopez-Villalobos N
dc.contributor.authorMcNaughton LR
dc.contributor.authorHickson RE
dc.contributor.editorAyaz A
dc.contributor.editorUllah F
dc.contributor.editorSaqib S
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-06-19T20:26:57Z
dc.date.available2024-06-19T20:26:57Z
dc.date.issued2023-04-01
dc.description.abstractThe objective of this study was to identify genomic regions and genes that are associated with the milk composition and fertility traits of spring-calved dairy cows in New Zealand. Phenotypic data from the 2014-2015 and 2021-2022 calving seasons in two Massey University dairy herds were used. We identified 73 SNPs that were significantly associated with 58 potential candidate genes for milk composition and fertility traits. Four SNPs on chromosome 14 were highly significant for both fat and protein percentages, and the associated genes were DGAT1, SLC52A2, CPSF1, and MROH1. For fertility traits, significant associations were detected for intervals from the start of mating to first service, the start of mating to conception, first service to conception, calving to first service, and 6-wk submission, 6-wk in-calf, conception to first service in the first 3 weeks of the breeding season, and not in calf and 6-wk calving rates. Gene Ontology revealed 10 candidate genes (KCNH5, HS6ST3, GLS, ENSBTAG00000051479, STAT1, STAT4, GPD2, SH3PXD2A, EVA1C, and ARMH3) that were significantly associated with fertility traits. The biological functions of these genes are related to reducing the metabolic stress of cows and increasing insulin secretion during the mating period, early embryonic development, foetal growth, and maternal lipid metabolism during the pregnancy period.
dc.description.confidentialfalse
dc.edition.editionApril 2023
dc.format.pagination860-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37107618
dc.identifier.citationJayawardana JMDR, Lopez-Villalobos N, McNaughton LR, Hickson RE. (2023). Genomic Regions Associated with Milk Composition and Fertility Traits in Spring-Calved Dairy Cows in New Zealand.. Genes (Basel). 14. 4. (pp. 860-).
dc.identifier.doi10.3390/genes14040860
dc.identifier.eissn2073-4425
dc.identifier.elements-typejournal-article
dc.identifier.issn2073-4425
dc.identifier.number860
dc.identifier.piigenes14040860
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/69921
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2073-4425/14/4/860
dc.relation.isPartOfGenes (Basel)
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectcandidate gene
dc.subjectdairy cattle
dc.subjectfertility
dc.subjectgenome-wide association study
dc.subjectmilk composition
dc.subjectPregnancy
dc.subjectFemale
dc.subjectCattle
dc.subjectAnimals
dc.subjectMilk
dc.subjectSeasons
dc.subjectLactation
dc.subjectNew Zealand
dc.subjectFertility
dc.subjectGenomics
dc.titleGenomic Regions Associated with Milk Composition and Fertility Traits in Spring-Calved Dairy Cows in New Zealand
dc.typeJournal article
pubs.elements-id461312
pubs.organisational-groupOther
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
Published version.pdf
Size:
1.95 MB
Format:
Adobe Portable Document Format
Description:
461312 PDF.pdf
Download
Thumbnail Image
Name:
Evidence.pdf
Size:
147.26 KB
Format:
Adobe Portable Document Format
Description:
genes-2294513-supplementary.pdf
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
9.22 KB
Format:
Plain Text
Description:
Download
Collections
Journal Articles