Novel, potentially zoonotic paramyxoviruses from the African straw-colored fruit bat Eidolon helvum

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dc.citation.issue3
dc.citation.volume87
dc.contributor.authorBaker KS
dc.contributor.authorTodd S
dc.contributor.authorMarsh GA
dc.contributor.authorCrameri G
dc.contributor.authorBarr J
dc.contributor.authorKamins AO
dc.contributor.authorPeel AJ
dc.contributor.authorYu M
dc.contributor.authorHayman DTS
dc.contributor.authorNadjm B
dc.contributor.authorMtove G
dc.contributor.authorAmos B
dc.contributor.authorReyburn H
dc.contributor.authorNyarko E
dc.contributor.authorSuu-Ire R
dc.contributor.authorMurcia PR
dc.contributor.authorCunningham AA
dc.contributor.authorWood JLN
dc.contributor.authorWang L-F
dc.date.available2013-02
dc.date.issued2013
dc.description.abstractBats carry a variety of paramyxoviruses that impact human and domestic animal health when spillover occurs. Recent studies have shown a great diversity of paramyxoviruses in an urban-roosting population of straw-colored fruit bats in Ghana. Here, we investigate this further through virus isolation and describe two novel rubulaviruses: Achimota virus 1 (AchPV1) and Achimota virus 2 (AchPV2). The viruses form a phylogenetic cluster with each other and other bat-derived rubulaviruses, such as Tuhoko viruses, Menangle virus, and Tioman virus. We developed AchPV1- and AchPV2-specific serological assays and found evidence of infection with both viruses in Eidolon helvum across sub-Saharan Africa and on islands in the Gulf of Guinea. Longitudinal sampling of E. helvum indicates virus persistence within fruit bat populations and suggests spread of AchPVs via horizontal transmission. We also detected possible serological evidence of human infection with AchPV2 in Ghana and Tanzania. It is likely that clinically significant zoonotic spillover of chiropteran paramyxoviruses could be missed throughout much of Africa where health surveillance and diagnostics are poor and comorbidities, such as infection with HIV or Plasmodium sp., are common.
dc.description.publication-statusPublished
dc.format.extent1348 - 1358
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000313558100006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef
dc.identifier.citationJOURNAL OF VIROLOGY, 2013, 87 (3), pp. 1348 - 1358
dc.identifier.doi10.1128/JVI.01202-12
dc.identifier.elements-id220110
dc.identifier.harvestedMassey_Dark
dc.identifier.issn0022-538X
dc.publisherAmerican Society for Microbiology
dc.relation.isPartOfJOURNAL OF VIROLOGY
dc.subject.anzsrc06 Biological Sciences
dc.subject.anzsrc07 Agricultural and Veterinary Sciences
dc.subject.anzsrc11 Medical and Health Sciences
dc.titleNovel, potentially zoonotic paramyxoviruses from the African straw-colored fruit bat Eidolon helvum
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Sciences
pubs.organisational-group/Massey University/College of Sciences/School of Veterinary Science
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