Comparative transcriptomes reveal geographic differences in the ability of the liver of plateau zokors (Eospalax baileyi) to respond and adapt to toxic plants

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dc.citation.issue1
dc.citation.volume24
dc.contributor.authorTan Y
dc.contributor.authorWang Y
dc.contributor.authorLiu Q
dc.contributor.authorWang Z
dc.contributor.authorShi S
dc.contributor.authorSu J
dc.coverage.spatialEngland
dc.date.accessioned2024-11-11T19:17:36Z
dc.date.available2024-11-11T19:17:36Z
dc.date.issued2023-12
dc.description.abstractBACKGROUND: Environmental changes are expected to intensify in the future. The invasion of toxic plants under environmental changes may change herbivore feeding environments. Herbivores living long-term in toxic plant-feeding environments will inevitably ingest plant secondary metabolites (PSMs), and under different feeding environments are likely to have unique protection mechanisms that support improved adaptation to PSMs in their habitat. We aimed to compare different subterranean herbivore population responses and adaptations to toxic plants to unveil their feeding challenges. RESULTS: Here, we investigated the adaptive capacity of the liver in two geographically separated populations of plateau zokors (Eospalax baileyi) before and after exposure to the toxic plant Stellera chamaejasme (SC), at the organ, biochemical, and transcriptomic levels. The results showed no significant liver granules or inflammatory reactions in the Tianzhu (TZ) population after the SC treatment. The transaminase level in the TZ population was significantly lower than that in the Luqu population. Transcriptome analysis revealed that the TZ population exhibited interactions with other detoxification metabolic pathways by oxytocin pathway-associated genes, including diacylglycerol lipase alpha (Dagla), calcium/calmodulin dependent protein kinase II Alpha (Camk2a), and CD38 molecule (Cd38). The phase II process of liver drug metabolism increased to promote the rate of metabolism. We found that alternative splicing (AS) and the expression of the cyclin D (Ccnd1) gene interact-a TZ population hallmark-reduced liver inflammatory responses. CONCLUSION: Our study supports the detoxification limitation hypothesis that differences in liver detoxification metabolism gene expression and AS are potential factors in herbivore adaptation to PSMs and may be a strategy of different herbivore populations to improve toxic plant adaptability.
dc.description.confidentialfalse
dc.edition.editionDecember 2023
dc.format.pagination529-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37674113
dc.identifier.citationTan Y, Wang Y, Liu Q, Wang Z, Shi S, Su J. (2023). Comparative transcriptomes reveal geographic differences in the ability of the liver of plateau zokors (Eospalax baileyi) to respond and adapt to toxic plants.. BMC Genomics. 24. 1. (pp. 529-).
dc.identifier.doi10.1186/s12864-023-09642-5
dc.identifier.eissn1471-2164
dc.identifier.elements-typejournal-article
dc.identifier.issn1471-2164
dc.identifier.number529
dc.identifier.pii10.1186/s12864-023-09642-5
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71960
dc.languageeng
dc.publisherBioMed Central Ltd
dc.publisher.urihttps://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-023-09642-5
dc.relation.isPartOfBMC Genomics
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAdaptive capacity
dc.subjectComparative transcriptome
dc.subjectDetoxify
dc.subjectPlateau zokor
dc.subjectStellera chamaejasme
dc.subjectPlants, Toxic
dc.subjectTranscriptome
dc.subjectLiver
dc.subjectGene Expression Profiling
dc.subjectAcclimatization
dc.titleComparative transcriptomes reveal geographic differences in the ability of the liver of plateau zokors (Eospalax baileyi) to respond and adapt to toxic plants
dc.typeJournal article
pubs.elements-id480268
pubs.organisational-groupOther
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