A cross-sectional investigation of Leptospira at the wildlife-livestock interface in New Zealand

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dc.citation.issue9
dc.citation.volume17
dc.contributor.authorMoinet M
dc.contributor.authorOosterhof H
dc.contributor.authorNisa S
dc.contributor.authorHaack N
dc.contributor.authorWilkinson DA
dc.contributor.authorAberdein D
dc.contributor.authorRussell JC
dc.contributor.authorVallée E
dc.contributor.authorCollins-Emerson J
dc.contributor.authorHeuer C
dc.contributor.authorBenschop J
dc.contributor.editorStevenson B
dc.coverage.spatialUnited States
dc.date.accessioned2024-04-30T02:31:54Z
dc.date.accessioned2024-07-25T06:42:44Z
dc.date.available2023-09-06
dc.date.available2024-04-30T02:31:54Z
dc.date.available2024-07-25T06:42:44Z
dc.date.issued2023-09-06
dc.description.abstractThere has been a recent upsurge in human cases of leptospirosis in New Zealand, with wildlife a suspected emerging source, but up-to-date knowledge on this topic is lacking. We conducted a cross-sectional study in two farm environments to estimate Leptospira seroprevalence in wildlife and sympatric livestock, PCR/culture prevalence in wildlife, and compare seroprevalence and prevalence between species, sex, and age groups. Traps targeting house mice (Mus musculus), black rats (Rattus rattus), hedgehogs (Erinaceus europaeus) and brushtail possums (Trichosurus vulpecula) were set for 10 trap-nights in March-April 2017 on a dairy (A) and a beef and sheep (B) farm. Trapped wild animals and an age-stratified random sample of domestic animals, namely cattle, sheep and working dogs were blood sampled. Sera were tested by microagglutination test for five serogroups and titres compared using a Proportional Similarity Index (PSI). Wildlife kidneys were sampled for culture and qPCR targeting the lipL32 gene. True prevalence in mice was assessed using occupancy modelling by collating different laboratory results. Infection profiles varied by species, age group and farm. At the MAT cut-point of ≥ 48, up to 78% of wildlife species, and 16-99% of domestic animals were seropositive. Five of nine hedgehogs, 23/105 mice and 1/14 black rats reacted to L. borgpetersenii sv Ballum. The sera of 4/18 possums and 4/9 hedgehogs reacted to L. borgpetersenii sv Hardjobovis whilst 1/18 possums and 1/9 hedgehogs reacted to Tarassovi. In ruminants, seroprevalence for Hardjobovis and Pomona ranged 0-90% and 0-71% depending on the species and age group. Titres against Ballum, Tarassovi and Copenhageni were also observed in 4-20%, 0-25% and 0-21% of domestic species, respectively. The PSI indicated rodents and livestock had the most dissimilar serological responses. Three of nine hedgehogs, 31/105 mice and 2/14 rats were carrying leptospires (PCR and/or culture positive). True prevalence estimated by occupancy modelling in mice was 38% [95% Credible Interval 26, 51%] on Farm A and 22% [11, 40%] on Farm B. In the same environment, exposure to serovars found in wildlife species was commonly detected in livestock. Transmission pathways between and within species should be assessed to help in the development of efficient mitigation strategies against Leptospira.
dc.description.confidentialfalse
dc.format.paginatione0011624-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37672535
dc.identifier.citationMoinet M, Oosterhof H, Nisa S, Haack N, Wilkinson DA, Aberdein D, Russell JC, Vallée E, Collins-Emerson J, Heuer C, Benschop J. (2023). A cross-sectional investigation of Leptospira at the wildlife-livestock interface in New Zealand.. PLoS Negl Trop Dis. 17. 9. (pp. e0011624-).
dc.identifier.doi10.1371/journal.pntd.0011624
dc.identifier.eissn1935-2735
dc.identifier.elements-typejournal-article
dc.identifier.issn1935-2727
dc.identifier.numbere0011624
dc.identifier.piiPNTD-D-23-00267
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70727
dc.languageeng
dc.publisherPLOS
dc.publisher.urihttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0011624
dc.relation.isPartOfPLoS Negl Trop Dis
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectDogs
dc.subjectHumans
dc.subjectAnimals
dc.subjectMice
dc.subjectRats
dc.subjectCattle
dc.subjectSheep
dc.subjectAnimals, Wild
dc.subjectLivestock
dc.subjectCross-Sectional Studies
dc.subjectLeptospira
dc.subjectNew Zealand
dc.subjectHedgehogs
dc.subjectSeroepidemiologic Studies
dc.subjectAnimals, Domestic
dc.titleA cross-sectional investigation of Leptospira at the wildlife-livestock interface in New Zealand
dc.typeJournal article
pubs.elements-id480232
pubs.organisational-groupOther
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