Unravelling the reservoirs for colonisation of infants with Campylobacter spp. in rural Ethiopia: protocol for a longitudinal study during a global pandemic and political tensions.

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dc.citation.issue10
dc.citation.volume12
dc.contributor.authorHavelaar AH
dc.contributor.authorBrhane M
dc.contributor.authorAhmed IA
dc.contributor.authorKedir J
dc.contributor.authorChen D
dc.contributor.authorDeblais L
dc.contributor.authorFrench N
dc.contributor.authorGebreyes WA
dc.contributor.authorHassen JY
dc.contributor.authorLi X
dc.contributor.authorManary MJ
dc.contributor.authorMekuria Z
dc.contributor.authorIbrahim AM
dc.contributor.authorMummed B
dc.contributor.authorOjeda A
dc.contributor.authorRajashekara G
dc.contributor.authorRoba KT
dc.contributor.authorSaleem C
dc.contributor.authorSingh N
dc.contributor.authorUsmane IA
dc.contributor.authorYang Y
dc.contributor.authorYimer G
dc.contributor.authorMcKune S
dc.coverage.spatialEngland
dc.date.accessioned2024-01-23T01:29:04Z
dc.date.accessioned2024-07-25T06:47:22Z
dc.date.available2022-10-05
dc.date.available2024-01-23T01:29:04Z
dc.date.available2024-07-25T06:47:22Z
dc.date.issued2022-10-05
dc.description.abstractINTRODUCTION: Undernutrition is an underlying cause of mortality in children under five (CU5) years of age. Animal-source foods have been shown to decrease malnutrition in CU5. Livestock are important reservoirs for Campylobacter bacteria, which are recognised as risk factors for child malnutrition. Increasing livestock production may be beneficial for improving nutrition of children but these benefits may be negated by increased exposure to Campylobacter and research is needed to evaluate the complex pathways of Campylobacter exposure and infection applicable to low-income and middle-income countries. We aim to identify reservoirs of infection with Campylobacter spp. of infants in rural Eastern Ethiopia and evaluate interactions with child health (environmental enteric dysfunction and stunting) in the context of their sociodemographic environment. METHODS AND ANALYSIS: This longitudinal study involves 115 infants who are followed from birth to 12 months of age and are selected randomly from 10 kebeles of Haramaya woreda, East Hararghe zone, Oromia region, Ethiopia. Questionnaire-based information is obtained on demographics, livelihoods, wealth, health, nutrition and women empowerment; animal ownership/management and diseases; and water, sanitation and hygiene. Faecal samples are collected from infants, mothers, siblings and livestock, drinking water and soil. These samples are analysed by a range of phenotypic and genotypic microbiological methods to characterise the genetic structure of the Campylobacter population in each of these reservoirs, which will support inference about the main sources of exposure for infants. ETHICS AND DISSEMINATION: Ethical approval was obtained from the University of Florida Internal Review Board (IRB201903141), the Haramaya University Institutional Health Research Ethics Committee (COHMS/1010/3796/20) and the Ethiopia National Research Ethics Review Committee (SM/14.1/1059/20). Written informed consent is obtained from all participating households. Research findings will be disseminated to stakeholders through conferences and peer-reviewed journals and through the Feed the Future Innovation Lab for Livestock Systems.
dc.description.confidentialfalse
dc.edition.editionOctober 2022
dc.format.paginatione061311-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/36198455
dc.identifier.citationHavelaar AH, Brhane M, Ahmed IA, Kedir J, Chen D, Deblais L, French N, Gebreyes WA, Hassen JY, Li X, Manary MJ, Mekuria Z, Ibrahim AM, Mummed B, Ojeda A, Rajashekara G, Roba KT, Saleem C, Singh N, Usmane IA, Yang Y, Yimer G, McKune S. (2022). Unravelling the reservoirs for colonisation of infants with Campylobacter spp. in rural Ethiopia: protocol for a longitudinal study during a global pandemic and political tensions.. BMJ Open. 12. 10. (pp. e061311-).
dc.identifier.doi10.1136/bmjopen-2022-061311
dc.identifier.eissn2044-6055
dc.identifier.elements-typejournal-article
dc.identifier.issn2044-6055
dc.identifier.numbere061311
dc.identifier.piibmjopen-2022-061311
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70877
dc.languageeng
dc.publisherBMJ Publishing Group Ltd
dc.publisher.urihttps://bmjopen.bmj.com/content/12/10/e061311
dc.relation.isPartOfBMJ Open
dc.rights(c) The author/sen
dc.rights.licenseCC BY 4.0en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectBACTERIOLOGY
dc.subjectEpidemiology
dc.subjectNutrition
dc.subjectPublic health
dc.subjectCampylobacter
dc.subjectDrinking Water
dc.subjectEthiopia
dc.subjectHumans
dc.subjectInfant
dc.subjectInfant, Newborn
dc.subjectLongitudinal Studies
dc.subjectMalnutrition
dc.subjectPandemics
dc.subjectSoil
dc.titleUnravelling the reservoirs for colonisation of infants with Campylobacter spp. in rural Ethiopia: protocol for a longitudinal study during a global pandemic and political tensions.
dc.typeJournal article
pubs.elements-id457151
pubs.organisational-groupOther
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