The Inhibitory Effects of New Zealand Pine Bark (Enzogenol®) on α-Amylase, α-Glucosidase, and Dipeptidyl Peptidase-4 (DPP-4) Enzymes.

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dc.citation.issue8
dc.citation.volume14
dc.contributor.authorLim WXJ
dc.contributor.authorGammon CS
dc.contributor.authorvon Hurst P
dc.contributor.authorChepulis L
dc.contributor.authorPage RA
dc.coverage.spatialSwitzerland
dc.date.accessioned2023-06-20T03:37:18Z
dc.date.available2022-04-12
dc.date.available2022-04-08
dc.date.available2023-06-20T03:37:18Z
dc.date.issued2022-04-12
dc.description.abstractThe New Zealand pine bark extract (Enzogenol®) has previously been shown to elicit acute hypoglycaemic effects in humans. The present study investigated the underlying mechanisms of Enzogenol® in reducing postprandial glucose in humans. The potential inhibitory action of Enzogenol® against digestive enzymes: α-amylase and α-glucosidase, and dipeptidyl peptidase-4 (DPP-4) enzyme was determined. Enzogenol® demonstrated the ability to inhibit all three enzymes: α-amylase enzyme activity (IC50 3.98 ± 0.11 mg/mL), α-glucosidase enzyme activity (IC50 13.02 ± 0.28 μg/mL), and DPP-4 enzyme activity (IC50 2.51 ± 0.04 mg/mL). The present findings indicate the potential for Enzogenol® to improve postprandial glycaemia by delaying carbohydrate digestion via the inhibition of digestive enzymes (α-amylase and α-glucosidase), and enhancing the incretin effect via inhibiting the dipeptidyl-peptidase-4 enzyme. The inhibitory actions of Enzogenol® on enzymes should therefore be further validated in humans for its potential use in type 2 diabetes mellitus prevention and management.
dc.description.publication-statusPublished online
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/35458159
dc.identifiernu14081596
dc.identifier.citationNutrients, 2022, 14 (8)
dc.identifier.doi10.3390/nu14081596
dc.identifier.eissn2072-6643
dc.identifier.elements-id452838
dc.identifier.harvestedMassey_Dark
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.relation.isPartOfNutrients
dc.rightsCC BY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectfunctional food
dc.subjecthyperglycaemia
dc.subjecthypoglycaemic effects
dc.subjectimpaired glycaemic control
dc.subjectincretin effect
dc.subjectpolyphenol
dc.subjectstarch inhibition
dc.subjectDiabetes Mellitus, Type 2
dc.subjectDipeptidyl-Peptidase IV Inhibitors
dc.subjectFlavonoids
dc.subjectGlycoside Hydrolase Inhibitors
dc.subjectHumans
dc.subjectNew Zealand
dc.subjectPinus
dc.subjectPlant Bark
dc.subjectPlant Extracts
dc.subjectQuercetin
dc.subjectalpha-Amylases
dc.subjectalpha-Glucosidases
dc.subject.anzsrc0908 Food Sciences
dc.subject.anzsrc1111 Nutrition and Dietetics
dc.titleThe Inhibitory Effects of New Zealand Pine Bark (Enzogenol®) on α-Amylase, α-Glucosidase, and Dipeptidyl Peptidase-4 (DPP-4) Enzymes.
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Health
pubs.organisational-group/Massey University/College of Health/PVC's Office - College of Health
pubs.organisational-group/Massey University/College of Health/School of Health Science
pubs.organisational-group/Massey University/College of Health/School of Sport, Exercise and Nutrition
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