The impact of heat treatment of bovine milk on gastric emptying and nutrient appearance in peripheral circulation in healthy females: a randomized controlled trial comparing pasteurized and ultra-high temperature milk

Simple item page
dc.citation.issue5
dc.citation.volume119
dc.contributor.authorMilan AM
dc.contributor.authorBarnett MPG
dc.contributor.authorMcNabb WC
dc.contributor.authorRoy NC
dc.contributor.authorCoutinho S
dc.contributor.authorHoad CL
dc.contributor.authorMarciani L
dc.contributor.authorNivins S
dc.contributor.authorSharif H
dc.contributor.authorCalder S
dc.contributor.authorDu P
dc.contributor.authorGharibans AA
dc.contributor.authorO'Grady G
dc.contributor.authorFraser K
dc.contributor.authorBernstein D
dc.contributor.authorRosanowski SM
dc.contributor.authorSharma P
dc.contributor.authorShrestha A
dc.contributor.authorMithen RF
dc.coverage.spatialUnited States
dc.date.accessioned2024-10-22T19:19:47Z
dc.date.available2024-10-22T19:19:47Z
dc.date.issued2024-05-01
dc.description.abstractBACKGROUND: Heat treatments of dairy, including pasteurization and ultra-high temperature (UHT) processing, alter milk macromolecular structures, and ultimately affect digestion. In vitro, animal, and human studies show faster nutrient release or circulating appearance after consuming UHT milk (UHT-M) compared with pasteurized milk (PAST-M), with a faster gastric emptying (GE) rate proposed as a possible mechanism. OBJECTIVES: To investigate the impact of milk heat treatment on GE as a mechanism of faster nutrient appearance in blood. We hypothesized that GE and circulating nutrient delivery following consumption would be faster for UHT-M than PAST-M. METHODS: In this double-blind randomized controlled cross-over trial, healthy female (n = 20; 27.3 ± 1.4 y, mean ± SD) habitual dairy consumers, consumed 500 mL of either homogenized bovine UHT-M or PAST-M (1340 compared with 1320 kJ). Gastric content volume (GCV) emptying half-time (T50) was assessed over 3 h by magnetic resonance imaging subjective digestive symptoms, plasma amino acid, lipid and B vitamin concentrations, and gastric myoelectrical activity were measured over 5 h. RESULTS: Although GCV T50 did not differ (102 ± 7 min compared with 89 ± 8 min, mean ± SEM, UHT-M and PAST-M, respectively; P = 0.051), GCV time to emptying 25% of the volume was 31% longer following UHT-M compared with PAST-M (42 ± 2 compared with 32 ± 4 min, P = 0.004). Although GCV remained larger for a longer duration following UHT-M (treatment × time interaction, P = 0.002), plasma essential amino acid AUC was greater following UHT-M than PAST-M (55,324 ± 3809 compared with 36,598 ± 5673 μmol·min·L-1, P = 0.006). Heat treatment did not impact gastric myoelectrical activity, plasma appetite hormone markers or subjective appetite scores. CONCLUSIONS: Contrary to expectations, GE was slower with UHT-M, yet, as anticipated, aminoacidemia was greater. The larger GCV following UHT-M suggests that gastric volume may poorly predict circulating nutrient appearance from complex food matrices. Dairy heat treatment may be an effective tool to modify nutrient release by impacting digestion kinetics. CLINICAL TRIAL REGISTRY: www.anzctr.org.au (ACTRN12620000172909).
dc.description.confidentialfalse
dc.edition.editionMay 2024
dc.format.pagination1200-1215
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/38452857
dc.identifier.citationMilan AM, Barnett MP, McNabb WC, Roy NC, Coutinho S, Hoad CL, Marciani L, Nivins S, Sharif H, Calder S, Du P, Gharibans AA, O'Grady G, Fraser K, Bernstein D, Rosanowski SM, Sharma P, Shrestha A, Mithen RF. (2024). The impact of heat treatment of bovine milk on gastric emptying and nutrient appearance in peripheral circulation in healthy females: a randomized controlled trial comparing pasteurized and ultra-high temperature milk.. Am J Clin Nutr. 119. 5. (pp. 1200-1215).
dc.identifier.doi10.1016/j.ajcnut.2024.03.002
dc.identifier.eissn1938-3207
dc.identifier.elements-typejournal-article
dc.identifier.issn0002-9165
dc.identifier.piiS0002-9165(24)00337-X
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71802
dc.languageeng
dc.publisherElsevier Inc on behalf of the American Society for Nutrition
dc.publisher.urihttps://www.sciencedirect.com/science/article/pii/S000291652400337X
dc.relation.isPartOfAm J Clin Nutr
dc.rights(c) 2024 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectMRI
dc.subjectamino acids
dc.subjectbody surface gastric mapping
dc.subjectdairy
dc.subjectdigestion
dc.subjectfood structure
dc.subjectgastric emptying
dc.subjectmilk
dc.subjectpasteurized milk
dc.subjectultra-high temperature milk
dc.subjectGastric Emptying
dc.subjectFemale
dc.subjectAnimals
dc.subjectHumans
dc.subjectMilk
dc.subjectAdult
dc.subjectHot Temperature
dc.subjectCattle
dc.subjectPasteurization
dc.subjectDouble-Blind Method
dc.subjectCross-Over Studies
dc.subjectNutrients
dc.subjectYoung Adult
dc.titleThe impact of heat treatment of bovine milk on gastric emptying and nutrient appearance in peripheral circulation in healthy females: a randomized controlled trial comparing pasteurized and ultra-high temperature milk
dc.typeJournal article
pubs.elements-id488062
pubs.organisational-groupOther
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
Published version.pdf
Size:
2.1 MB
Format:
Adobe Portable Document Format
Description:
488062 PDF.pdf
Download
Thumbnail Image
Name:
Evidence.docx
Size:
4.96 MB
Format:
Microsoft Word XML
Description:
1-s2.0-S000291652400337X-mmc1.docx
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
9.22 KB
Format:
Plain Text
Description:
Download
Collections
Journal Articles