Effects of nonsteroidal anti-inflammatory drugs, therapeutic hoof trimming, and orthopedic block application on lameness in multiparous dairy cattle: A randomized controlled trial

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dc.citation.issue4
dc.citation.volume108
dc.contributor.authorWilson JP
dc.contributor.authorGreen MJ
dc.contributor.authorRandall LV
dc.contributor.authorRutland CS
dc.contributor.authorBell NJ
dc.contributor.authorHemingway-Arnold H
dc.contributor.authorThompson JS
dc.contributor.authorBollard NJ
dc.contributor.authorHuxley JN
dc.date.accessioned2025-05-20T20:12:32Z
dc.date.available2025-05-20T20:12:32Z
dc.date.issued2025-04
dc.description.abstractHoof horn lesions are recurrent in nature and cause long-term pathological challenges to the functional anatomy of the hoof in dairy cattle. It is hypothesized that inflammation is a driver of these pathological changes. It has previously been identified that routine treatment with nonsteroidal anti-inflammatory drugs (NSAID) at first and subsequent calving and lameness events is important in reducing the future risk of lameness in dairy heifers. The effects NSAID administration has on lameness outcomes for multiparous dairy cattle is unknown. We conducted a 34-mo randomized controlled trial to investigate the effects of routine administration of the NSAID ketoprofen during treatment for lameness and at calving on the future probability of lameness and culling caused by exposure to normal farm conditions. Dairy cattle that had calved at least once were recruited from a single herd and randomly allocated to 1 of 4 treatments controlling for parity, proportion of occasions scored as lame 8 wk before study onset, and DIM. All lactating animals were scored for lameness every 2 wk to identify lame animals requiring treatment. Animals in group 1 received a therapeutic trim and an orthopedic hoof block (if deemed necessary) every time they were treated for lameness. Animals in group 2 received a 3-d course of ketoprofen (single dose daily) alongside the same treatment given in group 1 every time they were treated for lameness. Animals in group 3 received a 3-d course of ketoprofen (single dose daily) starting 24 to 36 h after each calving alongside the same treatment given in group 2 for lameness. Animals in group 4 received a 3-d course of ketoprofen (single dose daily) every time they were identified with lameness, with no therapeutic trim, unless they were identified as severely lame (a single score ≥3a). Animals were followed for the 34-mo duration of the study. Independent lameness outcome scores were collected every 2 wk by technicians who were blinded to treatment group to assess the probability of lameness. Culling data were extracted from farm records. A total of 425 animals were recruited to the study (105 in group 1, 107 in group 2, 107 in group 3, and 106 in group 4), with data from 412 animals included in the final analysis (102 in group 1, 102 in group 2, 106 in group 3, and 102 in group 4). The effect of treatment group on the ongoing probability of lameness was evaluated through the use of mixed effect logistic regression models. Compared with animals in group 1, animals in group 4 were significantly more likely to be identified as lame throughout the study period. No effect on the risk of severe lameness was identified. The effect of group on time to culling was investigated using a Cox proportional hazards model. No benefit of the NSAID or hoof trimming intervention on culling risk was identified. Our results highlight the importance of frequent therapeutic trimming and the application of orthopedic blocks in the treatment of lameness in multiparous animals that may have a history of calving and lameness without NSAID administration.
dc.description.confidentialfalse
dc.edition.editionApril 2025
dc.format.pagination4194-4205
dc.identifier.citationWilson JP, Green MJ, Randall LV, Rutland CS, Bell NJ, Hemingway-Arnold H, Thompson JS, Bollard NJ, Huxley JN. (2025). Effects of nonsteroidal anti-inflammatory drugs, therapeutic hoof trimming, and orthopedic block application on lameness in multiparous dairy cattle: A randomized controlled trial. Journal of Dairy Science. 108. 4. (pp. 4194-4205).
dc.identifier.doi10.3168/jds.2024-25442
dc.identifier.eissn1525-3198
dc.identifier.elements-typejournal-article
dc.identifier.issn0022-0302
dc.identifier.piiS0022030225000669
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/72917
dc.languageEnglish
dc.publisherElsevier Inc for the American Dairy Science Association, USA
dc.publisher.urihttps://www.sciencedirect.com/science/article/pii/S0022030225000669
dc.relation.isPartOfJournal of Dairy Science
dc.rights(c) 2025 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectdairy cow
dc.subjectNSAID
dc.subjectlameness
dc.subjecthoof horn lesion
dc.subjecthoof trimming
dc.titleEffects of nonsteroidal anti-inflammatory drugs, therapeutic hoof trimming, and orthopedic block application on lameness in multiparous dairy cattle: A randomized controlled trial
dc.typeJournal article
pubs.elements-id500585
pubs.organisational-groupOther
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