"Nourish to Flourish": complementary feeding for a healthy infant gut microbiome-a non-randomised pilot feasibility study.

Simple item page
dc.citation.issue1
dc.citation.volume8
dc.contributor.authorLovell AL
dc.contributor.authorEriksen H
dc.contributor.authorMcKeen S
dc.contributor.authorMullaney J
dc.contributor.authorYoung W
dc.contributor.authorFraser K
dc.contributor.authorAltermann E
dc.contributor.authorGasser O
dc.contributor.authorKussmann M
dc.contributor.authorRoy NC
dc.contributor.authorMcNabb WC
dc.contributor.authorWall CR
dc.coverage.spatialEngland
dc.date.accessioned2024-08-09T03:03:51Z
dc.date.available2024-08-09T03:03:51Z
dc.date.issued2022-05-18
dc.description.abstractBACKGROUND: The introduction of complementary foods and changes in milk feeding result in modifications to gastrointestinal function. The interplay between indigestible carbohydrates, host physiology, and microbiome, and immune system development are areas of intense research relevant to early and later-life health. METHODS: This 6-month prospective non-randomised feasibility study was conducted in Auckland, New Zealand (NZ), in January 2018. Forty parents/caregivers and their infants were enrolled, with 30 infants allocated to receive a prebiotic NZ kūmara (flesh and skin; a type of sweet potato) prepared as a freeze-dried powder, and ten infants allocated to receive a commercially available probiotic control known to show relevant immune benefits (109 CFU Bifidobacterium lactis BB-12®). The primary outcome was the study feasibility measures which are reported here. RESULTS: Recruitment, participant retention, and data collection met feasibility targets. Some limitations to biological sample collection were encountered, with difficulties in obtaining sufficient plasma sample volumes for the proposed immune parameter analyses. Acceptability of the kūmara powder was met with no reported adverse events. CONCLUSION: This study indicates that recruiting infants before introducing complementary foods is feasible, with acceptable adherence to the food-based intervention. These results will inform the protocol of a full-scale randomised controlled trial (RCT) with adjustments to the collection of biological samples to examine the effect of a prebiotic food on the prevalence of respiratory tract infections during infancy. Trial registration Australia New Zealand Clinical Trials Registry ACTRN12618000157279 . Prospectively registered on 02/01/2018.
dc.description.confidentialfalse
dc.edition.edition2022
dc.format.pagination103-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/35585649
dc.identifier.citationLovell AL, Eriksen H, McKeen S, Mullaney J, Young W, Fraser K, Altermann E, Gasser O, Kussmann M, Roy NC, McNabb WC, Wall CR. (2022). "Nourish to Flourish": complementary feeding for a healthy infant gut microbiome-a non-randomised pilot feasibility study.. Pilot Feasibility Stud. 8. 1. (pp. 103-).
dc.identifier.doi10.1186/s40814-022-01059-3
dc.identifier.eissn2055-5784
dc.identifier.elements-typejournal-article
dc.identifier.issn2055-5784
dc.identifier.number103
dc.identifier.pii10.1186/s40814-022-01059-3
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71249
dc.languageeng
dc.publisherSpringer Nature Limited.
dc.publisher.urihttps://pilotfeasibilitystudies.biomedcentral.com/articles/10.1186/s40814-022-01059-3
dc.relation.isPartOfPilot Feasibility Stud
dc.rights(c) 2022 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectComplementary feeding
dc.subjectFeasibility
dc.subjectImmune health
dc.subjectInfant
dc.subjectMicrobiome
dc.title"Nourish to Flourish": complementary feeding for a healthy infant gut microbiome-a non-randomised pilot feasibility study.
dc.typeJournal article
pubs.elements-id453586
pubs.organisational-groupOther
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
Published version.pdf
Size:
1.09 MB
Format:
Adobe Portable Document Format
Description:
453586 PDF.pdf
Download
Thumbnail Image
Name:
Evidence.docx
Size:
34.92 KB
Format:
Microsoft Word XML
Description:
40814_2022_1059_MOESM1_ESM.docx
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
9.22 KB
Format:
Plain Text
Description:
Download
Collections
Journal Articles