Does chronic oral contraceptive use detrimentally affect C-reactive protein or iron status for endurance-trained women?

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dc.citation.issue14
dc.citation.volume11
dc.contributor.authorBadenhorst CE
dc.contributor.authorGovus AD
dc.contributor.authorMündel T
dc.coverage.spatialUnited States
dc.date.accessioned2024-06-19T20:43:34Z
dc.date.available2024-06-19T20:43:34Z
dc.date.issued2023-07-24
dc.description.abstractPURPOSE: Chronic use of the oral contraceptive pill (OCP) is reported to increase C-reactive protein (CRP) levels and increase the risk of cardiovascular disease in premenopausal females. METHODS: A secondary analysis of data from two research studies in eumenorrheic (n = 8) and OCP (n = 8) female athletes. Basal CRP and iron parameters were included in the analysis. Sample collection occurred following a standardized exercise and nutritional control for 24 h. Eumenorrheic females were tested in the early-follicular and mid-luteal phases, and the OCP users were tested in quasi-follicular and quasi-luteal phases (both active pill periods). RESULTS: A main effect for group (p < 0.01) indicated that average CRP concentration was higher in OCP users compared with eumenorrheic females, regardless of the day of measurement within the cycle. Results demonstrate a degree of iron parameters moderation throughout the menstrual cycle that is influenced by basal CRP levels; however, no linear relationship with CRP, serum iron, and ferritin was observed. CONCLUSIONS: Basal CRP values were consistently higher in the OCP group despite participants being in a rested state. These results may indicate a potential risk of cardiovascular disease in prolonged users of the OCP when compared to eumenorrheic female athletes.
dc.description.confidentialfalse
dc.edition.editionJul 2023
dc.format.paginatione15777-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37487629
dc.identifier.citationBadenhorst CE, Govus AD, Mündel T. (2023). Does chronic oral contraceptive use detrimentally affect C-reactive protein or iron status for endurance-trained women?. Physiol Rep. 11. 14. (pp. e15777-).
dc.identifier.doi10.14814/phy2.15777
dc.identifier.eissn2051-817X
dc.identifier.elements-typejournal-article
dc.identifier.issn2051-817X
dc.identifier.numbere15777
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/69925
dc.languageeng
dc.publisherWiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.
dc.publisher.urihttps://physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.15777
dc.relation.isPartOfPhysiol Rep
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectcardiovascular risk
dc.subjectexercise
dc.subjectfemales
dc.subjectinflammation
dc.subjectovarian hormones
dc.subjectHumans
dc.subjectFemale
dc.subjectIron
dc.subjectC-Reactive Protein
dc.subjectCardiovascular Diseases
dc.subjectFerritins
dc.subjectContraceptives, Oral
dc.titleDoes chronic oral contraceptive use detrimentally affect C-reactive protein or iron status for endurance-trained women?
dc.typeJournal article
pubs.elements-id479163
pubs.organisational-groupCollege of Health
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