Collagen dehydration

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dc.citation.volume216
dc.contributor.authorHaverkamp RG
dc.contributor.authorSizeland KH
dc.contributor.authorWells HC
dc.contributor.authorKamma-Lorger C
dc.coverage.spatialNetherlands
dc.date.available2022-09-01
dc.date.available2022-06-27
dc.date.issued1/09/2022
dc.description.abstractType I collagen is a ubiquitous structural protein in animal tissues. It is normally present in a hydrated form. However, collagen is very dependent on associated water for its mechanical properties. In skin, where type I collagen is dominant, there is a longstanding concern that the skin and therefore collagen may partially dry out and result in structural degradation. Here we show that dehydration of type I collagen fibrils, using 2-propanol, results in a two-stage dehydration process. Initially, the fibrils do not change length, i.e. the D-period remains constant, but shrinkage occurs within the fibrils by an increase in the gap region and a decrease in the overlap region within a D-band and a shortening of the helical turn distance and fibril diameter. Only with further dehydration does the length of the collagen fibril decrease (a decrease in D-period). This mechanism explains why collagen materials are resistant to gross structural change in the early stages of dehydration and shows why they may then suffer from sudden external shrinkage with further dehydration.
dc.description.publication-statusPublished
dc.format.extent140 - 147
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/35793742
dc.identifierS0141-8130(22)01393-9
dc.identifier.citationInt J Biol Macromol, 2022, 216 pp. 140 - 147
dc.identifier.doi10.1016/j.ijbiomac.2022.06.180
dc.identifier.eissn1879-0003
dc.identifier.elements-id454559
dc.identifier.harvestedMassey_Dark
dc.identifier.urihttps://hdl.handle.net/10179/17461
dc.languageeng
dc.publisherElsevier BV
dc.relation.isPartOfInt J Biol Macromol
dc.relation.urihttps://doi.org/10.1016/j.ijbiomac.2022.06.180
dc.subjectCollagen
dc.subjectDehydration
dc.subjectSmall angle X-ray scattering
dc.subjectAnimals
dc.subjectCollagen
dc.subjectCollagen Type I
dc.subjectDehydration
dc.subjectExtracellular Matrix
dc.subjectSkin
dc.subject.anzsrc0601 Biochemistry and Cell Biology
dc.titleCollagen dehydration
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Sciences
pubs.organisational-group/Massey University/College of Sciences/School of Food and Advanced Technology
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