Lower-Than-Expected Vitamin A Concentrations in a Commercial Diet Associated with Uroliths and Pyelonephritis in Rats

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dc.citation.issue10
dc.citation.volume12
dc.contributor.authorMunday JS
dc.contributor.authorCastillo-Alcala F
dc.contributor.authorJaros P
dc.contributor.editorSatou T
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-01-17T20:55:50Z
dc.date.accessioned2024-07-25T06:51:38Z
dc.date.available2022-05-18
dc.date.available2024-01-17T20:55:50Z
dc.date.available2024-07-25T06:51:38Z
dc.date.issued2022-05-18
dc.description.abstractFive of 95 rats in an oral safety study developed uroliths, with two of these rats also developing pyelonephritis. Histology of the urinary tract revealed squamous metaplasia suggestive of vitamin A deficiency. Analysis of the diet showed around half the expected concentration of vitamin A, although the concentrations were close to the published nutritional requirements for rats. Due to the presence of squamous metaplasia of the transitional epithelium and the low vitamin A concentration in the diet, a presumptive diagnosis of vitamin A deficiency was made, although an interaction between the low vitamin A concentrations and other dietary components appears possible. Although the uroliths did not cause clinical signs of disease, the lesions observed during this study could have been misinterpreted as being due to the test substance. Observations from this study highlight the need for high-quality food to ensure background lesions do not develop when performing safety studies in rats.
dc.description.confidentialfalse
dc.edition.editionMay 2022
dc.format.pagination1288-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/35625134
dc.identifier.citationMunday JS, Castillo-Alcala F, Jaros P. (2022). Lower-Than-Expected Vitamin A Concentrations in a Commercial Diet Associated with Uroliths and Pyelonephritis in Rats.. Animals (Basel). 12. 10. (pp. 1288-).
dc.identifier.doi10.3390/ani12101288
dc.identifier.eissn2076-2615
dc.identifier.elements-typejournal-article
dc.identifier.issn2076-2615
dc.identifier.number1288
dc.identifier.piiani12101288
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71043
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2076-2615/12/10/1288
dc.relation.isPartOfAnimals (Basel)
dc.rights(c) 2022 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectexperimental diets
dc.subjectnephrolith
dc.subjectnutrition
dc.subjecttoxicity study
dc.subjectvitamin A
dc.subjectvitamin deficiency
dc.titleLower-Than-Expected Vitamin A Concentrations in a Commercial Diet Associated with Uroliths and Pyelonephritis in Rats
dc.typeJournal article
pubs.elements-id453566
pubs.organisational-groupOther
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